Protective effects of antioxidants on acrylonitrile-induced oxidative stress in female F344 rats

Environmental Toxicology
Xinzhu PuJ E Klaunig

Abstract

The induction of oxidative stress and damage appears to be involved in acrylonitrile induction of brain astrocytomas in rat. The present study examined the effects of dietary antioxidant supplementation on acrylonitrile-induced oxidative stress and oxidative damage in rats in vivo. To assess the effects of antioxidants on biomarkers of acrylonitrile-induced oxidative stress, female F344 rats were provided with diets containing vitamin E (0.05%), green tea polyphenols (GTP, 0.4%), N-acetyl cysteine (NAC, 0.3%), sodium selenite (0.1mg/kg), and taurine (10g/kg) for 7 days, and then co-administered with 0 and 100 ppm acrylonitrile in drinking water for 28 days. Significant increase in oxidative DNA damage in brain, evidenced by elevated 8OHdG levels, was seen in acrylonitrile-exposed rats. Supplementation with vitamin E, GTP, and NAC reduced acrylonitrile-induced oxidative DNA damage in brain while no protective effects were seen with the selenium or taurine supplementation. Acrylonitrile increased oxidative DNA damage, measured by the fpg-modified alkaline Comet assay in rat WBCs, which was reduced by supplementation of Vitamin E, GTP, NAC, selenium, and taurine. In addition to stimulation of oxidative DNA damage, acrylonitrile tr...Continue Reading

References

Jan 1, 1991·Advances in Experimental Medicine and Biology·R R TiceN P Singh
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Feb 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D D BignerH S Friedman
Jan 1, 1984·Environmental Mutagenesis·T W Kensler, M A Trush
Jan 1, 1984·Methods in Enzymology·R P Bird, H H Draper
Nov 1, 1995·Toxicology and Applied Pharmacology·G L KedderisM J Turner
Oct 1, 1996·Toxicology and Applied Pharmacology·G L KedderisM L Gargas
Nov 14, 1997·The Journal of Nutrition·J Y YehP D Whanger
Aug 7, 1998·Regulatory Toxicology and Pharmacology : RTP·J WhysnerG M Williams
Aug 26, 1998·Archives of Toxicology·J WhysnerG M Williams
Jan 27, 1999·Methods in Enzymology·H J HelbockB N Ames
Mar 6, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·E RojasM Valverde
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Nov 11, 1999·European Journal of Clinical Nutrition·I T Johnson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Nov 19, 2002·Mutagenesis·Andrew Collins, Vikki Harrington
Jan 30, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ah Siew SimDavid Emil Leon Wilcken
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·James E Klaunig, Lisa M Kamendulis
Apr 29, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Raquel MateosLaura Bravo
Nov 2, 2004·Biological Trace Element Research·Mubeen Ahmad AnsariFakhrul Islam
Sep 21, 2005·Journal of Biochemical and Molecular Toxicology·Cristina DiodovichLaura Gribaldo
Sep 28, 2005·Neurochemical Research·V G NicolettiA M Giuffrida Stella
Feb 17, 2006·Biochimica Et Biophysica Acta·Charles GulloGerrard Teoh
Aug 19, 2006·Environmental and Molecular Mutagenesis·Xinzhu PuJames E Klaunig
Jun 22, 2007·Nature·Sheila S DavidSucharita Kundu
Aug 30, 2008·Journal of Biochemical and Molecular Toxicology·El-Sayed M El-SayedGamil M Abd-Alla
May 26, 2009·Neurochemistry International·Lu RongzhuMichael Aschner
Jun 24, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xinzhu PuJames E Klaunig

❮ Previous
Next ❯

Citations

Dec 6, 2016·Nutrients·Amaya Azqueta, Andrew Collins
Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
Dec 8, 2017·Journal of Cellular Physiology·Shu-Jie HuangAndy T Y Lau
Apr 6, 2020·Toxicology Letters·Andrew CollinsAmaya Azqueta
Jun 13, 2020·Chemical Research in Toxicology·Vernon E WalkerJames A Swenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis