Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice

Inflammation
Rui-Ling LuanWei Jiang

Abstract

This study aimed to investigate the protective effects of apigenin against paraquat (PQ)-induced acute lung injury (ALI) in mice. Male Kunming mice were randomly divided into five groups: group 1 (control), group 2 (PQ), group 3 (PQ + apigenin 25 mg/kg), group 4 (PQ + apigenin 50 mg/kg), and group 5 (PQ + apigenin 100 mg/kg). The PQ + apigenin group received apigenin by gavage daily for consecutive 7 days, respectively, while the mice in control and PQ groups were given an equivalent volume of saline. We detected the lung wet/dry weight ratios and the histopathology of the lung. The levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were determined using enzyme-linked immunosorbent assay (ELISA) kits. The activity of nuclear factor (NF)-κB was also determined. The results indicated that apigenin administration decreased biochemical parameters of inflammation and oxidative stress, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of apigenin were associated with inhibition of NF-κB. In conclusion, apigenin reduces PQ-induced ALI by inhibition of inflammation an...Continue Reading

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Citations

Mar 11, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Zsófia Edit PápayIstván Antal
Mar 25, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Ioannis BougioukasBernhard C Danner
Nov 4, 2020·Journal of Biochemical and Molecular Toxicology·Xialei WuHaibin Wu
Feb 3, 2021·Critical Reviews in Toxicology·Rajasekaran Subbiah, Rajnarayan R Tiwari
Mar 16, 2021·Frontiers in Pharmacology·Xinyi MaDingsheng Lin

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