Protective effects of APOE e2 against disease progression in subcortical vascular mild cognitive impairment patients: A three-year longitudinal study

Scientific Reports
Yeo Jin KimHee Jin Kim

Abstract

Although the association between apolipoprotein E (APOE) genotype and disease progression is well characterized in patients with Alzheimer's disease, such a relationship is unknown in patients with subcortical vascular cognitive impairment. We evaluated whether APOE genotype is associated with disease progression in subcortical vascular mild cognitive impairment (svMCI) patients. We prospectively recruited 72 svMCI patients (19 APOE4 carriers, 42 APOE3 homozygotes, and 11 APOE2 carriers). Patients were annually followed-up with brain MRI and neuropsychological tests for three years and underwent a second Pittsburgh compound B (PiB)-PET at a mean interval of 32.3 months. Amyloid-ß burden was quantified by PiB standardized uptake value ratio (SUVR), and the amount of small vessel disease was quantified by number of lacune and small vessel disease score on MRI. We also measured cortical thickness. During the three years of follow-up, compared to the APOE3 homozygotes, there was less increase in PiB SUVR among APOE2 carriers (p = 0.023), while the APOE genotype did not show significant effects on small vessel disease progression. APOE2 carriers also showed less cortical thinning (p = 0.023) and a slower rate of cognitive decline (p...Continue Reading

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Citations

Aug 7, 2019·Aging Cell·Paola SebastianiThomas T Perls
Oct 26, 2018·Circulation Research·Cristina GiulianiClaudio Franceschi
Sep 30, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Noemí Lamonja-VicenteMarc Via
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Nov 21, 2020·Journal of Alzheimer's Disease : JAD·Mengtian DuPaola Sebastiani
Jul 1, 2020·Neurobiology of Aging·Brian J LoprestiDana L Tudorascu
Jul 2, 2021·Alzheimer's Research & Therapy·May A BeydounAlan B Zonderman
Jul 25, 2021·Translational Psychiatry·Hei Man WuPaul F O'Reilly
Aug 10, 2021·Journal of Alzheimer's Disease : JAD·Benjamin SweigartPaola Sebastiani

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Software Mentioned

PASW Statistics
PiB
Matlab
Surfstat
AAL
SPM

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