PMID: 9528919Apr 7, 1998Paper

Protective effects of aptiganel HCl (Cerestat) following controlled cortical impact injury in the rat

Journal of Neurotrauma
S N KroppenstedtA W Unterberg

Abstract

Recent studies have demonstrated a neuroprotective effect of the noncompetitive N-methyl-D-aspartate receptor antagonist aptiganel HCl (Cerestat) in focal cerebral ischemia. In the present study, we investigated the protective ability of aptiganel HCl after controlled cortical impact injury (impact depth = 2 mm; impactor velocity = 7 mm/sec) of the left temporoparietal cortex in rats. Intravenous aptiganel HCl (2 mg/kg) or a respective volume of vehicle was injected 15 min after trauma. Animals were sacrificed 24 h after trauma. Contusion volume was measured planimetrically from hematoxylin-eosin-stained coronal slices. Hemispheric swelling and water content were determined gravimetrically. Thirty minutes before sacrifice, a Codman intracranial pressure (ICP) probe was placed in the right hemisphere, and ICP as well as mean arterial blood pressure (MABP) and cerebral perfusion pressure (CPP) were monitored. Aptiganel HCl reduced contusion volume by 13.6% in treated rats (p < 0.05). Hemispheric swelling was also significantly diminished by 31.5% in accordance to a decrease in hemispheric water content (controls, 82.78 +/- 0.12%, vs. aptiganel HCl, 82.30 +/- 0.18%, p < 0.05). Posttraumatic ICP was not significantly lower in the a...Continue Reading

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Citations

Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·P M Lea, A I Faden
Jun 24, 2010·Journal of Neurotrauma·Guo WeiFrank C Tortella
Mar 6, 1999·Journal of Neurosurgery·S N KroppenstedtA W Unterberg
Jul 7, 2000·Journal of Neurosurgery·J Cruz
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anat BiegonEsther Shohami
Feb 17, 2000·Current Opinion in Neurology·H L Laurer, T K McIntosh
Aug 14, 1999·Journal of Neurotrauma·S N KroppenstedtA W Unterberg
Mar 14, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rami YakaEsther Shohami

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