Protective effects of aspirin against oxidized LDL-induced inflammatory protein expression in human endothelial cells

Journal of Cardiovascular Pharmacology
Jinjing ZhaoShuzheng Lu

Abstract

Atherosclerosis is a complex vascular inflammatory disease. Oxidized low-density lipoprotein (ox-LDL) is directly associated with chronic vascular inflammation. In this study, we hypothesized that nonselective cyclooxygenase inhibitor aspirin might affect the ox-LDL-induced inflammatory responses on human endothelial cells. To test this assumption, cyclooxygenase-2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1) expression, IkappaB and p38 mitogen-activated protein kinase (MAPK) phosphorylation were determined in endothelial cells exposed to ox-LDL in the presence of aspirin. The results showed that aspirin significantly suppressed COX-2 and ICAM-1 expression induced by ox-LDL and also inhibited IkappaB phosphorylation in human umbilical vein endothelial cells (HUVECs). Moreover, aspirin reduced the level of p38 MAPK phosphorylation. Our findings suggest that aspirin can decrease inflammatory responses induced by ox-LDL, and the mechanism might be associated with NF-kappaB activation pathway and inhibition of p38 MAPK phosphorylation.

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Citations

Dec 24, 2013·Journal of Molecular Endocrinology·Rong WanShengnan Li
Jan 16, 2014·Critical Care : the Official Journal of the Critical Care Forum·Nai-Wen TsaiCheng-Hsien Lu
Nov 26, 2008·Neurologic Clinics·R Charles Callison, Harold P Adams
Dec 30, 2014·Critical Reviews in Clinical Laboratory Sciences·Andreja TrpkovicEsma R Isenovic
Jun 24, 2009·Journal of Cardiovascular Pharmacology·Luis Ulisses SignoriBeatriz D'Agord Schaan

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