Protective effects of Carissa opaca fruits against CCl4-induced oxidative kidney lipid peroxidation and trauma in rat

Food & Nutrition Research
Sumaira SahreenHuda Mohammad Alkreathy

Abstract

Carbon tetrachloride (CCl4) is a potent nephrotoxin, as it causes acute as well as chronic toxicity in kidneys. Therefore, this study was carried out to assess the pharmacological potential of different fractions of Carissa opaca fruits on CCl4-induced oxidative trauma in the kidney. The parameters studied in this respect were the kidney function tests viz, serum profile, urine profile, genotoxicity, characteristic morphological findings, and antioxidant enzymatic level of kidneys. The protective effects of various fractions of C. opaca fruits against CCl4 administration were reviewed by rat renal function alterations. Chronic toxicity caused by 8-week treatment of CCl4 to the rats significantly decreased the pH level, activities of antioxidant enzymes, and glutathione contents, whereas a significant increase was found in the case of specific gravity, red blood cells, white blood cells, level of urea, and lipid peroxidation in comparison to control group. Administration of various fractions of C. opaca fruit with CCl4 showed protective ability against CCl4 intoxication by restoring the urine profile, activities of antioxidant enzymes, and lipid peroxidation in rat. CCl4 induction in rats also caused DNA fragmentation and glomer...Continue Reading

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Citations

May 29, 2016·BMC Complementary and Alternative Medicine·Moniba SajidDereje Nigussie
Jun 22, 2019·Environmental Science and Pollution Research International·Wael N HozzeinHind M S Alharbi
Aug 18, 2016·BMC Complementary and Alternative Medicine·Shumaila Jan, Muhammad Rashid Khan
Jan 24, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Godswill Nduka AnyasorOluwafemi Kale
Dec 5, 2019·Natural Product Research·Basma Khalaf MahmoudMohamed Salah Kamel
Sep 2, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·N EhsanS Mahboob

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Methods Mentioned

BETA
chromosomal aberrations

Software Mentioned

SPSS

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