Protective Effects of Carvacrol against Oxidative Stress Induced by Chronic Stress in Rat's Brain, Liver, and Kidney

Biochemistry Research International
Saeed SamarghandianAbasalt Borji

Abstract

Restraint stress may be associated with elevated free radicals, and thus, chronic exposure to oxidative stress may cause tissue damage. Several studies have reported that carvacrol (CAR) has a protective effect against oxidative stress. The present study was designed to investigate the protective effects of CAR on restraint stress induced oxidative stress damage in the brain, liver, and kidney. For chronic restraint stress, rats were kept in the restrainers for 6 h every day, for 21 consecutive days. The animals received systemic administrations of CAR daily for 21 days. To evaluate the changes of the oxidative stress parameters following restraint stress, the levels of malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and catalase (CAT) activities were measured in the brain, liver, and kidney. In the stressed animals that received vehicle, the MDA level was significantly higher (P < 0.001) and the levels of GSH and antioxidant enzymes were significantly lower than the nonstressed animals (P < 0.001). CAR ameliorated the changes in the stressed animals as compared with the control group (P < 0.001). This study indicates that CAR can prevent re...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Jan 1, 1967·The Journal of Pediatrics·L F Hill
Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R AeschbachO I Aruoma
Jul 15, 1993·European Journal of Biochemistry·H Sies
Mar 18, 2000·Toxicology Letters·R C StrangeA A Fryer
Jul 6, 2000·Progress in Neurobiology·R Dringen
Nov 21, 2001·The Journal of Biological Chemistry·Sharda P SinghPiotr Zimniak
Jul 13, 2004·International Journal of Food Microbiology·Sara Burt
Feb 25, 2005·Nature Reviews. Drug Discovery·Frank E Koehn, Guy T Carter
Dec 13, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Emel Sahin, Saadet Gümüşlü
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cheryl D ConradRyan L Wright
Nov 17, 2009·Fundamental & Clinical Pharmacology·Francisca Helvira Cavalcante MeloFrancisca Cléa Florenço de Sousa
Jan 2, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·N P SudheeshK K Janardhanan
Jan 19, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vanita GuptaRatan Kumar
Jul 9, 2010·Fundamental & Clinical Pharmacology·Francisca Helvira Cavalcante MeloFrancisca Cléa Florenço de Sousa
Jul 17, 2010·The International Journal of Neuropsychopharmacology·Jeremy W GawrylukL Trevor Young
Jul 20, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Alireza Timcheh HaririHossein Hosseinzadeh
Sep 21, 2010·Basic & Clinical Pharmacology & Toxicology·Adriana G GuimarãesLucindo J Quintans-Júnior
Apr 7, 2012·Life Sciences·Wei Zhe Liang, Cheng Hsien Lu
Feb 2, 2013·International Journal of Biological Macromolecules·Ke PanDewu Zhong
Oct 15, 2014·Experimental Animals·Saeed SamarghandianFariborz Samini
Jan 16, 2016·Journal of Biochemical and Molecular Toxicology·Balakrishnan AristatileKodukkur Viswanathan Pugalendi
Feb 11, 2016·Canadian Journal of Physiology and Pharmacology·Saeed SamarghandianTahereh Farkhondeh

❮ Previous
Next ❯

Citations

Feb 9, 2017·Canadian Journal of Physiology and Pharmacology·Sibel GunesRuhi Uyar
Jul 12, 2017·Dose-response : a Publication of International Hormesis Society·Saeed SamarghandianMohsen Azimi-Nezhad
Dec 22, 2017·International Journal of Molecular Sciences·Solomon Habtemariam
Jan 26, 2018·International Journal of Molecular Sciences·Weishun TianByung-Yong Park
Sep 16, 2017·Nutritional Neuroscience·Liming DongXinmin Liu
Jun 26, 2018·International Journal of Radiation Biology·Mohamed A El-MissiryMohamad F Lebede
Oct 15, 2018·Journal of Cellular Physiology·Entesar Ali SaberRanda Ahmed Ibrahim
Jun 10, 2016·Phytotherapy Research : PTR·Saeed SamarghandianTahereh Farkhondeh
Oct 31, 2017·Asian Pacific Journal of Tropical Medicine·Tahereh FarkhondehAbasalt Borji
Jul 13, 2018·Kidney Diseases·Hanieh Shaterzadeh-YazdiTahereh Farkhondeh
May 11, 2018·Phytotherapy Research : PTR·Mehdi Sharifi-RadJavad Sharifi-Rad
Dec 11, 2019·Biomolecules·Diogo Vilar da FonsêcaDamião Pergentino de Sousa
Apr 19, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Fatemeh Zare MehrjerdiMehdi Khaksari
Jan 30, 2018·PloS One·Douglas Carvalho CaixetaFoued Salmen Espindola
Dec 12, 2018·The Journal of Pharmacy and Pharmacology·Michelle Fonseca CostaAdriana Gibara Guimarães
Jan 22, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Juliana Silva SiqueiraCamila Renata Corrêa
Feb 7, 2020·Molecular and Cellular Endocrinology·Miriane de OliveiraCélia Regina Nogueira
Mar 4, 2021·Reproductive Biomedicine Online·Bircan KolbasiIlknur Keskin
Jan 1, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hamed ShooreiMajid Shokoohi
Apr 20, 2021·Journal of Medicinal Food·Ana Cristina JacobowskiMaria Lígia Rodrigues Macedo
May 14, 2021·Frontiers in Pharmacology·Bahare SalehiJavad Sharifi-Rad
May 25, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Alireza MortazaviMahmoud Hosseini
Oct 30, 2020·Life Sciences·Bianza Moise BakadiaGuang Yang
Mar 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammed A El-MissiryAli M AbouEl-Ezz

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
MDA

Software Mentioned

InStat

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.