Protective effects of Chunghyuldan against ROS-mediated neuronal cell death in models of Parkinson's disease

Basic & Clinical Pharmacology & Toxicology
Hyo Geun KimMyung Sook Oh

Abstract

Previous reports have suggested that the herbal medicine Chunghyuldan (CHD, Qingxue-dan in Chinese and Daio-Orengedokuto in Japanese) has wide-ranging biological effects, including anti-hyperlipidaemic, anti-ischaemic, anti-inflammatory and antioxidant activities. Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is thought to be one of the major pathological mechanisms responsible for Parkinson's disease (PD) and may underlie the selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) that is a hallmark of this disease. In this study, we examined the neuroprotective effects of CHD in PD models produced by treatment with neurotoxins that act via ROS-mediated mitochondrial dysfunction. In an in vitro PD model using 6-hydroxydopamine, CHD applied at concentrations of 10 and 100 μg/ml exhibited significant protective effects in PC12 cells by inhibiting intracellular ROS generation. CHD applied at 10 and 100 μg/ml also prevented 6-hydroxydopamine-induced mitochondrial depolarization and elevation of caspase-3 activity. At the same doses, CHD showed regulatory effects on the haem oxygenase-1 and gp91 phagocytic oxidase which have critical roles in generating ROS. In addition, CHD protected ...Continue Reading

References

Mar 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·E C HirschW C Olanow
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A HartmannE C Hirsch
Mar 20, 2001·Nature Reviews. Molecular Cell Biology·M P Mattson
Nov 7, 2002·Biological & Pharmaceutical Bulletin·Young-Suk KimDong-Hyun Kim
Jul 23, 2003·CNS Drugs·Silvia MandelMoussa B H Youdim
Dec 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christophe Lo BiancoPatrick Aebischer
Jun 25, 2005·The American Journal of Chinese Medicine·Ki Ho ChoSang Kwan Moon
Oct 13, 2006·Bioscience, Biotechnology, and Biochemistry·Wen-Hsin HuangChing-Huey Yang
Dec 7, 2007·Clinical Neuroscience Research·R Lee MosleyHoward E Gendelman
Jun 16, 2009·Canadian Journal of Physiology and Pharmacology·Kyong Nyon NamEunjoo H Lee
Aug 5, 2009·Biological & Pharmaceutical Bulletin·Hyun Ah JungJae Sue Choi

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Citations

May 14, 2014·Canadian Journal of Physiology and Pharmacology·Hyo Geun KimMyung Sook Oh
Oct 14, 2014·BMC Complementary and Alternative Medicine·Mei Yeng YewKhuen Yen Ng
Jan 12, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·In-Su KimDong-Kug Choi
Jan 16, 2016·Parkinson's Disease·Dan ChenManju B Reddy
Jan 4, 2012·Journal of Ethnopharmacology·Ju-Xian SongYan-Bo Zhang
Jun 13, 2015·Oxidative Medicine and Cellular Longevity·Carlos Fernández-MorianoM Pilar Gómez-Serranillos
Jan 7, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyo Geun KimMyung Sook Oh
Jun 25, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Woo-Sang JungKi-Ho Cho
Jun 28, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·S Sandoval-AvilaN E Díaz-Martínez
Feb 1, 2017·Cell Death and Differentiation·Jinbo ChengZengqiang Yuan
Sep 25, 2012·Basic & Clinical Pharmacology & Toxicology·Chun-hua LiuWei-zhi Wang
Feb 18, 2015·Journal of Neurochemistry·Carolina AlquézarÁngeles Martín-Requero
Jul 8, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Won-Woo ChoiYoungmin Bu
Dec 25, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Tae-Yeon HwangHi-Joon Park
Jul 12, 2020·Antioxidants·Kuo-Hsuan Chang, Chiung-Mei Chen
Aug 14, 2021·Metabolic Brain Disease·Awanish MishraNavneet Khurana

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