Protective effects of Citrus limonia oil against cisplatin-induced nephrotoxicity

Environmental Science and Pollution Research International
Mohamed M Abdel-DaimNoha A Salem

Abstract

Cisplatin is broadly used in the treatment of malignancies. However, the high incidence of nephrotoxicity following cisplatin use deters its clinical utility. Former studies have shown that the essential oils, obtained from Citrus limonia demonstrated significant anti-inflammatory and antioxidant effects. The aim of the current work was to evaluate the protective effects of Citrus limonia oil against cisplatin-induced nephrotoxicity. Thirty-two adult male mice were divided into four groups, eight mice each. The control group received distilled water, and the second group received a single intraperitoneal injection of cisplatin (20 mg/kg), while the third and fourth groups received cisplatin plus Citrus limonia oil at 100 or 200 mg/kg for 10 days, respectively. GC-MS analysis showed that the major components in Citrus limonia oil were D-limonene, 5-methyl-pentadecane, (n)-menthol, 3,7-dimethyl-(E)-2,6-octadienal, 3,7-dimethyl-2,6-octadienal, and nonadecane. Biochemical analysis showed that cisplatin intoxication was associated with significantly increased (p < 0.05) serum levels of urea and creatine and pro-inflammatory cytokines, as well as augmented renal tissue oxidative stress. Light microscopic examination showed loss of re...Continue Reading

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Citations

May 4, 2021·Environmental Science and Pollution Research International·Cihan GurMustafa Ileriturk
May 15, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chen GaoZhihui Hao
Jul 2, 2021·Journal of Advanced Research·Mohamed Gamal El-Din EweesBasim Anwar Shehata Messiha
Oct 1, 2021·Environmental Science and Pollution Research International·Mohamed Hussien, Mokhtar Ibrahim Yousef

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