Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells

Pharmacological Reports : PR
Lan-Ying ShiJian Qin

Abstract

Aging is one of the most important inevitable risk factors of Alzheimer disease (AD). Oxidative stress plays a critical role in the process of aging. Curcumin has been proposed to improve neural damage, especially neurodegenerative injury, through its antioxidant and anti-inflammatory properties. Therefore, we investigated the effects of curcumin on acrolein-induced AD-like pathologies in HT22 cells. HT22 murine hippocampal neuronal cells were treated with 25μM acrolein for 24h with or without pre-treating with curcumin at the selected optimum concentration (5μg/mL) for 30min. Cell viability and apoptosis were measured by CCK8 assay and flow cytometric analysis. Levels of glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA) were detected by a GSH assay kit or commercial assay kits, respectively. Alterations in the expression of BDNF/TrkB and key enzymes involved in amyloid precursor protein (APP) metabolism were assessed by western blotting. Data showed that curcumin significantly reversed acrolein-induced oxidative stress indicated by depletion of GSH and SOD, and elevation of MDA. The findings also suggested curcumin's potential in protecting HT22 cells against acrolein through regulating the BDNF/TrkB sig...Continue Reading

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Citations

Mar 4, 2020·Journal of Biochemical and Molecular Toxicology·Kabeer AbubakarMd Zuki Abu Bakar Zakaria
Sep 3, 2020·Neurotoxicity Research·Mona KhoramjouyMehrdad Faizi
Aug 19, 2020·Biomedicines·Andleeb KhanMuneeb U Rehman
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Feb 25, 2020·Environmental Science and Pollution Research International·Nebahat YildizbayrakMelike Erkan
Jan 5, 2021·Journal of Biochemical and Molecular Toxicology·Tauqeerunnisa Syeda, Jason R Cannon
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aliabbas ZiaSaeed Samarghandian
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Jan 22, 2021·The Cerebellum·Adaze Bijou Enogieru, Oghenakhogie Iroboudu Momodu

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