Abstract
Radioiodine (RI) treatment is widely used in patients with differentiated thyroid cancer. However, RI exposure often induces salivary gland (SG) dysfunction. In this study, we investigated the effect of curcumin on RI-induced SG dysfunction in mice. Mice were assigned to one of four groups (n = 6 per group) as follows: normal control, RI only, RI + curcumin, and RI + amifostine group. Salivary flow rate, lag time, and changes in 99m Tc (technetium)-pertechnetate uptake and excretion were measured, and changes in SG morphology and histology were analysed. Salivary epidermal growth factor content, amylase, and superoxide dismutase (SOD) activities were also measured. A terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was performed to assess SG apoptosis, and the expression of apoptosis-related protein was determined by western blotting. The reduced salivary flow rate and prolonged lag time in the RI group was restored by treatment with curcumin or amifostine. In the histological analysis, compared with the RI group, RI + curcumin and RI + amifostine groups had more mucin-rich acini and less periductal fibrosis. Compared with the RI group, RI + curcumin and RI + amifostine groups showed evidence of tissue remod...Continue Reading
References
Feb 7, 2001·European Journal of Nuclear Medicine·C VanhoveA Bossuyt
May 6, 2003·Thyroid : Official Journal of the American Thyroid Association·Susan J Mandel, Louis Mandel
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ricky A SharmaWilliam P Steward
Jul 3, 2007·The Oncologist·John R KouvarisLampros J Vlahos
Oct 16, 2007·Drug Discovery Today·Seyed Jalal Hosseinimehr
Mar 13, 2008·IEEE Transactions on Medical Imaging·Michel DefriseJohan Nuyts
Mar 29, 2008·Antioxidants & Redox Signaling·Alexios S Strimpakos, Ricky A Sharma
Jun 27, 2009·International Journal of Radiation Biology·Joseph F Weiss, Michael R Landauer
Sep 18, 2012·Oral Oncology·Jae-Yol LimYoung-Mo Kim
Nov 13, 2012·The AAPS Journal·Subash C GuptaBharat B Aggarwal
Jan 15, 2013·BioFactors·Rajesh L ThangapazhamRadha K Maheshwari
Apr 18, 2013·Current Medicinal Chemistry·A MarchianiP Ruzza
May 15, 2013·Neuroscience Letters·Junxiong MaLiangbi Xiang
Aug 2, 2013·Future Oncology·Zohreh Noaparast, Seyed Jalal Hosseinimehr
Aug 21, 2013·PloS One·Jae-Yol LimYoung-Mo Kim
Nov 6, 2013·Redox Biology·Joyce TrujilloJosé Pedraza-Chaverrí
May 29, 2014·Oxidative Medicine and Cellular Longevity·Jinzhou FengXinyue Qin
Sep 10, 2014·Life Sciences·Dania AkbikRamin Rohanizadeh
Jun 2, 2015·PloS One·Xunsi QinLan Li
Oct 16, 2015·Thyroid : Official Journal of the American Thyroid Association·Bryan R HaugenLeonard Wartofsky
Nov 4, 2015·PloS One·Hye-Young AnYoung-Mo Kim
Feb 3, 2016·The British Journal of Oral & Maxillofacial Surgery·Pia Lopez-JornetVicente Vicente-Ortega
May 3, 2016·Clinical and Experimental Otorhinolaryngology·Jeong-Seok ChoiJae-Yol Lim
Mar 8, 2017·Journal of Cancer Research and Clinical Oncology·Suzan SchwertheimSien-Yi Sheu-Grabellus
Citations
Jul 12, 2020·Head & Neck·Marc-Kevin Le RouxJean-Marc Foletti
Mar 5, 2020·Dose-response : a Publication of International Hormesis Society·Tingting ZhangRensheng Wang
Jul 30, 2021·Food & Function·Li ZhangJiandong Bao