Abstract
In pathogenesis of necrotizing enterocolitis (NEC), both oxidative stress and inflammation are considerable risk factors. The study was designed to evaluate whether administration of dexpanthenol (Dxp) is able to attenuate intestinal injury through the antioxidant and antiinflammatory mechanisms in a neonatal rat model of NEC. Forty newborn pups divided into four groups were included in the study: control, control+Dxp, NEC, and NEC+Dxp. NEC was induced by hyperosmolar formula and additionally the pups were exposed to hypoxia/hyperoxia and cold stress. They were sacrificed on postnatal day four, and their intestinal tissues were analyzed biochemically and histopathologically. Dxp caused a significant decrease in intestinal damage as determined by the histological score, villus height and number of goblet cells in NEC groups (p<0.0001). Tissue malondialdehyde, total oxidant status, and oxidative stress indexes levels were higher in the NEC group than in the control and control+Dxp groups (p<0.001). These values were reduced in the pups treated with Dxp (p≤0.004). Superoxide dismutase, glutathione peroxidase, and reduced glutathione activities were significantly reduced in the NEC group compared to the others (p<0.005). Treatment ...Continue Reading
References
Jun 1, 1990·The Journal of Pediatrics·M S CaplanJ R Hageman
Dec 1, 1995·Free Radical Biology & Medicine·V S SlyshenkovL Wojtczak
Jun 2, 1998·Free Radical Biology & Medicine·V S SlyshenkovL Wojtczak
May 23, 2001·Free Radical Biology & Medicine·V S SlyshenkovL Wojtczak
Aug 5, 2003·BioFactors·Lech Wojtczak, Vyacheslav S Slyshenkov
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jul 1, 2004·FEBS Letters·Vyacheslav S SlyshenkovLech Wojtczak
Jul 26, 2006·Pediatric Research·Javeed TravadiKaren Simmer
Sep 20, 2006·Pediatric Surgery International·Barlas EtenselHarun Gürsoy
Oct 13, 2006·Biochemical and Biophysical Research Communications·Yuning ZhouDai H Chung
Dec 15, 2010·Current Opinion in Pediatrics·Jennifer W Lee, Jonathan M Davis
Nov 15, 2011·Journal of Pediatric Surgery·Cumhur AydemirUgur Dilmen
Nov 15, 2011·Journal of Pediatric Surgery·Ahmet GuvenAhmet Korkmaz
Nov 14, 2012·Kidney & Blood Pressure Research·Ramazan AltintasGul Pelin Odabas
Feb 19, 2013·Clinics in Perinatology·Isabelle G De Plaen
Mar 8, 2013·The Journal of Surgical Research·Sadik YurttutanUgur Dilmen
Apr 25, 2013·Seminars in Pediatric Surgery·Mehul V RavalR Lawrence Moss
Apr 26, 2013·Neonatology·Ramazan OzdemirUgur Dilmen
Sep 3, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Hilal ErmisZeynep Ayfer Aytemur
Sep 28, 2013·Pediatric Surgery International·Sadık YurttutanUgur Dilmen
Citations
Apr 5, 2016·Scientifica·Amit Kumar DeShyamaprasad Chattapadhyay
Aug 19, 2016·Nature Reviews. Gastroenterology & Hepatology·Diego F NiñoDavid J Hackam
Feb 13, 2018·Biomedical Chromatography : BMC·Yilin WangRui Yang
Apr 8, 2020·Dermatologic Therapy·Ömer Kutlu
Aug 30, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Mustafa OgdenBulent Bakar
Jul 30, 2016·Inflammation·Wan Li-MeiYu Peng-Jiu
Nov 8, 2018·Experimental and Therapeutic Medicine·Yilmaz BilgicYusuf Turkoz
Nov 12, 2018·Journal of Pediatric Surgery·Christian PradoFelipe Dal-Pizzol
Apr 21, 2021·Drug and Chemical Toxicology·Mumin Alper ErdoganDilek Taskıran
Sep 22, 2021·Bioengineered·Ling Sun