Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway

British Journal of Pharmacology
Yimeng ZhangJinyong Peng

Abstract

Dioscin exhibits a range of pharmacological actions but little is known of its effects on cisplatin (CDDP)-induced nephrotoxicity. Here, we have assessed the effects and the possible mechanisms of dioscin against CDDP-induced nephrotoxicity. We used an in vivo model of CDDP-induced nephrotoxicity in rats and mice and, in vitro, cultures of NRK-52E and HK-2 cells. The dual luciferase reporter assay was used to demonstrate modulation, by dioscin, of the targeting of sirtuin 1 (Sirt1) by microRNA (miR)-34a. Molecular docking assays were used to analyse the effects of dioscin with Sirt1, Keap1 and NF-κB. Dioscin attenuated cell damage in vitro and decreased renal injury in rats and mice, treated with CDDP. In terms of mechanisms, dioscin reversed CDDP-induced up-regulation of miR-34a and thus up-regulated Sirt1 levels. In addition, dioscin altered levels of haem oxygenase 1, glutathione-cysteine ligase subunits (GCLC, GCLM) and Keap1, along with increased nuclear translocation of Nrf2, thus decreasing oxidative stress. Also, dioscin affected levels of AP-1, COX-2, HMGB1, IκB-α, IL-1β, IL-6 and TNF-α and decreased the ratio of acetylated NF-κB and normal NF-κB, to suppress inflammation. From molecular docking assays, dioscin directl...Continue Reading

References

Oct 24, 2001·Cell·H VaziriR A Weinberg
Sep 19, 2003·Seminars in Nephrology·Istvan Arany, Robert L Safirstein
Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
Jul 21, 2006·Cancer Chemotherapy and Pharmacology·Sherif Y SaadTawfeeg A Najjar
Feb 5, 2008·Toxicology·Yolanda I ChirinoJosé Pedraza-Chaverri
Feb 19, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Camila Salum OliveiraFrancesco Mattia Rossi
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Munekazu YamakuchiCharles J Lowenstein
Jul 4, 2009·Free Radical Biology & Medicine·Fei ZhaoDonna D Zhang
Jul 7, 2010·Cell·Graziano MartelloStefano Piccolo
Jul 7, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kazim SahinOmer Kucuk
Jul 24, 2010·British Journal of Pharmacology·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Apr 21, 2012·Environmental Toxicology and Pharmacology·Binan LuJinyong Peng
Aug 9, 2012·Clinical Pharmacology and Therapeutics·A M Bataille, J E Manautou
Dec 25, 2012·Biochimica Et Biophysica Acta·Jaeyong ChoDong Gun Lee
Jul 23, 2013·Journal of Hepatology·Bibo KeJerzy W Kupiec-Weglinski
Sep 14, 2013·Oncotarget·Niraj M ShahDavid J MacEwan
Dec 10, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hanan HagarOmina A Nayal
May 13, 2015·British Journal of Pharmacology·John C McGrath, Elliot Lilley
Jun 24, 2015·Toxicology Letters·Takatoshi Karasawa, Peter S Steyger
Jun 27, 2015·British Journal of Pharmacology·Michael J CurtisJohn C McGrath
Sep 9, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Meng QiJinyong Peng
Oct 21, 2015·Journal of Ethnopharmacology·Akhtolkhyn TilyekBoyang Yu
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderUNKNOWN CGTP Collaborators
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCgtp Collaborators
Mar 2, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Pratap ReddyP Sreenivasula Reddy
Jul 20, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Meng QiJinyong Peng

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Citations

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Nov 10, 2020·Environmental Science and Pollution Research International·Khalid Shaaban HashemMohamed M Abdel-Daim
Jun 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian ChenXiaogen Tao
Feb 23, 2020·Current Molecular Pharmacology·Vipin K VermaJagriti Bhatia
Mar 23, 2021·Acta Pharmacologica Sinica·Chun-Yan FangQin-Jie Weng
May 15, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chen GaoZhihui Hao
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