Protective Effects of Downregulating Estrogen Receptor Alpha Expression in Cervical Cancer

Anti-cancer Agents in Medicinal Chemistry
Ping YuJihong Wang

Abstract

The cause of cervical cancer can be traced to Human Papilloma Virus (HPV) along with other, nonviral factors. The uterine cervix is reactive to hormones, and female hormones have been implicated in cervical cancer pathogenesis. Previous studies have indicated that malignant cervical cells tend to lose Estrogen Receptor alpha (ER-α) expression in the cervical epithelium while maintaining ER-α expression in the stromal cells. We searched the Web of Science, Embase, PubMed, and Wiley Online Library databases to identify potentially relevant articles up to July 4, 2018. Keywords include uterine cervical neoplasms; receptors, estrogen; estrogen receptor alpha; estrogen receptor modulators; estrogens; cervical cancer and estrogen receptor. Discussions on molecular transitions and drug therapies offer insights into cervical cancer and the functions of estrogen receptors. We focus on molecular transitions and drug therapies for cervical cancer and ER-α targets. Finally, the targeting of downstream gene products and/or receptors to aid in cervical cancer prevention and therapy is discussed. Downregulating ER-α expression may be a potential treatment regimen for cervical cancer patients and will be of great significance for patients with...Continue Reading

Citations

Aug 2, 2019·Anti-cancer Agents in Medicinal Chemistry·Zhuandi GongSuocheng Wei
Sep 9, 2020·Critical Reviews in Oncology/hematology·Edgardo SomiglianaFedro Peccatori
Apr 1, 2021·Renal Failure·Hao-Yang MaYang Du

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