Protective effects of endothelin-1 on acute pancreatitis in rats

Digestive Diseases and Sciences
M KogireM Imamura

Abstract

Endothelin-1, a 21-residue peptide isolated from vascular endothelial cells, has a broad spectrum of actions. To clarify the involvement of endothelin-1 in acute pancreatitis, we examined the effects of endothelin-1 and its receptor antagonist BQ-123 on cerulein-induced pancreatitis in rats. Rats were infused intravenously with heparin-saline (control), endothelin-1 (100 pmol/kg/hr), cerulein (5 micrograms/kg/hr), or cerulein plus endothelin-1 for 3.5 hr. In another experiment, cerulein or cerulein plus BQ-123 (3 mg/kg/hr) was infused. Infusion of cerulein caused hyperamylasemia and pancreatic edema. Endothelin-1, when infused with cerulein, decreased the extent of pancreatic edema with a significant increase in the pancreatic dry- to wet-weight ratio. Histological changes induced by cerulein were markedly attenuated when endothelin-1 was given with cerulein. In contrast, endothelin-receptor blockade with BQ-123 further augmented pancreatic edema caused by cerulein. The extent of inflammatory cell infiltration was greater than BQ-123 was given with cerulein. Endothelin-1 or BQ-123 had no influence on hyperamylasemia. This study suggests that endothelin-1 has protective effects on experimental acute pancreatitis.

References

Nov 1, 1992·Archives of Surgery·M L Steer
Sep 1, 1992·The American Journal of the Medical Sciences·T HiranoT Tobe
Dec 17, 1992·The New England Journal of Medicine·K MooreK Badr
Jan 1, 1992·Life Sciences·K TakaoriT Tobe
Dec 1, 1990·Circulation·K B MarguliesJ C Burnett
Jan 1, 1989·Journal of Cardiovascular Pharmacology·C ThiemermannJ R Vane
Feb 7, 1989·European Journal of Pharmacology·S D Brain
Oct 1, 1988·The Journal of Pharmacy and Pharmacology·C L ChanderD A Willoughby
Jan 1, 1981·Prostaglandins·A TarnawskiB Klimczyk
Jan 1, 1981·Scandinavian Journal of Gastroenterology·M V SingerM I Grossman
May 1, 1993·Gastroenterology·M AsbertJ Rodés

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Citations

Mar 23, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Anna Andrzejewska, Jan W Dlugosz
Jul 17, 2004·Regulatory Peptides·Manabu GotoMasakazu Haneda
Nov 19, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jan W DlugoszEugeniusz Wroblewski
Jul 29, 1999·The Journal of Surgical Research·T PlusczykG Feifel
Nov 28, 2002·The Annals of Pharmacotherapy·Alexander A Fisher, Mark L Bassett
Jan 11, 2005·World Journal of Gastroenterology : WJG·You-Dai ChenXiao-Hui Peng
Apr 12, 2006·The British Journal of Surgery·C M Cuthbertson, C Christophi
Jun 11, 1999·The American Journal of Physiology·E von DobschuetzK Messmer
Jun 12, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·T PlusczykM Schilling
Feb 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B O Al-JiffryG T P Saccone

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