Protective effects of ethynylestradiol on the hemodynamic changes induced by lipopolysaccharide in anesthetized rats

Journal of Cardiovascular Pharmacology
B Palacios, C C Pang

Abstract

Estrogen pretreatment has been reported to protect rats from death induced by endotoxin. We investigated the effects of posttreatment with a synthetic estrogen, ethynylestradiol, on arterial pressure and hemodynamics in thiobutabarbitone-anesthetized rats challenged with Escherichia coli lipopolysaccharide. Rats were i.v. injected with lipopolysaccharide (1 mg/kg) followed by vehicle or a single dose of ethynylestradiol (0.25, 0.5, or 1 mg/kg) 1 h later. Another group (time-matched control) was given the vehicle. In the time-control group, there was a slight decrease in mean arterial pressure (-10 +/- 3 mm Hg) but no significant changes in cardiac output, total peripheral resistance, or heart rate over the 6-h study period. Lipopolysaccharide progressively reduced mean arterial pressure and cardiac output (-27 +/- 8 mm Hg and -52 +/- 6 ml/min, after 6 h) and increased total peripheral resistance and heart rate (+0.33 +/- 0.10 mm Hg/min/ml and +21 +/- 13 beats/min, after 6 h). None of the time-control rats died, but 36% of the rats treated with lipopolysaccharide died between 3 and 6 h after endotoxin challenge. Ethynylestradiol, at 0.25 and 0.5 completely, and at 1 mg/kg partially, restored mean arterial pressure and cardiac ou...Continue Reading

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Citations

Mar 23, 2012·Journal of Neurotrauma·Joshua W GatsonJoseph P Minei
Sep 13, 2001·Infection and Immunity·S M MerkelY M Huet-Hudson
Apr 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sándor BátkaiGeorge Kunos
Mar 27, 2003·Current Opinion in Critical Care·Yukihiro YokoyamaIrshad H Chaudry

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