Protective effects of evodiamine in experimental paradigm of Alzheimer's disease

Cognitive Neurodynamics
Dongmei WangSanqiang Li

Abstract

Evodiamine, a major component of Evodia rutaecarpa, has been reported to possess various pharmacological activities, including anti-inflammatory, antioxidative stress, and neuroprotective effects. Our previous study has shown that the potential effects of evodiamine on the learning and memory impairments in the transgenic mouse model of Alzheimer's disease (AD). The present study was designed to investigate neuroprotective mechanism and therapeutic potential of evodiamine against intracerebroventricular streptozotocin (ICV-STZ)-induced experimental sporadic Alzheimer's disease in mice. STZ was injected twice intracerebroventrically (3 mg/kg ICV) on alternate days (day 1 and day 3) in mice. Daily oral administration with evodiamine (50 or 100 mg/kg per day) starting from the first dose of STZ for 21 days showed an improvement in STZ induced cognitive deficits as assessed by novel object recognition and Morris water maze test. Evodiamine significantly decreased STZ induced elevation in acetylcholinesterase activity and malondialdehyde level, and significantly increased STZ induced reduction in glutathione activities and superoxide dismutase activities in the hippocampus compared to control. Furthermore, evodiamine inhibited signi...Continue Reading

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Citations

May 18, 2019·Journal of Cellular Biochemistry·Ersen EraslanZeliha Yetim
Jul 11, 2020·Molecular Biology Reports·Parisa AzadfarPejman Mortazavi
Jun 3, 2021·International Journal of Molecular Sciences·Ching-Hsuan Chou, Chia-Ron Yang

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Methods Mentioned

BETA
dissection
MDA
light microscopy
ELISA

Software Mentioned

Pro Plus
ImageScope Viewer
Ethovison XT
Aperio
Image
SPSS

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