Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw.

The Journal of Trauma
Shibani PatiJohn B Holcomb

Abstract

Clinical studies have shown that resuscitation with fresh frozen plasma (FFP) is associated with improved outcome after severe hemorrhagic shock (HS). We hypothesized that in addition to its effects on hemostasis, FFP has protective and stabilizing effects on the endothelium that translate into diminished endothelial cell (EC) permeability and improved resuscitation in vivo after HS. We further hypothesized that the beneficial effects of FFP would diminish over 5 days of routine storage at 4 degrees C. EC permeability was induced by hypoxia and assessed by the passage of 70-kDa Dextran between monolayers. Thrombin generation time and coagulation factor levels or activity were assessed in FFP. An in vivo rat model of HS and resuscitation was used to determine the effects of FFP on hemodynamic stability. Thawed FFP inhibits EC permeability in vitro by 10.2-fold. Protective effects diminish (to 2.5-fold) by day 5. Thrombin generation time is increased in plasma that has been stored between days 0 and 5. In vivo data show that day 0 FFP is superior to day 5 FFP in maintaining mean arterial pressure in rats undergoing HS with resuscitation. Both in vitro and in vivo studies show that FFP has beneficial effects on endothelial permeab...Continue Reading

References

Apr 29, 1998·The Journal of Clinical Investigation·C C SillimanD R Ambruso
May 7, 1998·Transfusion Medicine·I Chin-YeeG Moses
Feb 12, 2000·American Journal of Surgery·G ZallenC C Silliman
Sep 19, 2003·Pathophysiology of Haemostasis and Thrombosis·H C HemkerS Béguin
Sep 8, 2004·Thrombosis and Haemostasis·Erik R VandendriesBruce Furie
Jun 21, 2005·British Journal of Anaesthesia·D R Spahn, R Rossaint
Jan 9, 2007·Transfusion·Erik A ScottKenneth D Friedman
Jan 12, 2007·The Journal of Trauma·Ernest A GonzalezBruce A McKinley
Nov 21, 2007·Hematology·John R Hess
Jan 25, 2008·Thrombosis and Haemostasis·Saskia E M ScholsElisabeth C M van Pampus
Apr 23, 2008·Current Protocols in Protein Science·John F CarpenterTheodore W Randolph
May 2, 2008·Critical Care Medicine·Christopher C Silliman
Sep 17, 2008·BMC Medical Genomics·Susann SchenkMatthias Mann
Sep 19, 2008·The New England Journal of Medicine·Ralph L Nachman, Shahin Rafii
Oct 14, 2008·The Journal of Trauma·John R HessBertil Bouillon
Nov 13, 2008·The Journal of Trauma·Jason L SperryUNKNOWN Inflammation the Host Response to Injury Investigators
Dec 20, 2008·American Journal of Surgery·Frederick A MooreUNKNOWN StO2 Study Group
Jan 14, 2009·Blood Reviews·Sarah B MurthiJohn R Hess
Mar 12, 2009·The Journal of Trauma·Pedro G R TeixeiraPeter Rhee
Apr 1, 2009·Shock·Brian B ChesebroMitchell J Cohen
Apr 25, 2009·Current Opinion in Anaesthesiology·Tim FrenzelMartin Westphal
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Joel M BaumgartnerMartin D McCarter
Jun 19, 2009·The New England Journal of Medicine·Rakesh K Jain
Dec 8, 2009·Blood·Patrizia Comoli

❮ Previous
Next ❯

Citations

Jan 11, 2011·The Journal of Trauma·Nena MatijevicJohn B Holcomb
Nov 11, 2011·The Journal of Trauma·Phillip A LetourneauJohn B Holcomb
Aug 27, 2011·Critical Care : the Official Journal of the Critical Care Forum·Bryan C Oh, John B Holcomb
Jun 17, 2010·Critical Care : the Official Journal of the Critical Care Forum·John B Holcomb
Feb 25, 2011·Anesthesia and Analgesia·Rosemary A KozarAngel Paredes
Sep 3, 2011·PloS One·Ricky J Haywood-WatsonRosemary A Kozar
Jul 13, 2012·Journal of Emergencies, Trauma, and Shock·Pär I JohanssonSisse R Ostrowski
Apr 1, 2014·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·S A Savage, T C Fabian
Aug 30, 2014·Clinics in Laboratory Medicine·Arun Saini, Philip C Spinella
Jan 28, 2016·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·D T Martin, M A Schreiber
Dec 15, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Q LiuC Quintini
Dec 15, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jerard Seghatchian, Jeffrey S Putter
Aug 1, 2012·Transfusion·Robert C GosselinDouglas Taylor
Jan 18, 2013·Transfusion·Geir StrandenesPhilip C Spinella
Jan 18, 2013·Transfusion·Kevin R Ward
Apr 19, 2011·Transfusion·Philip C SpinellaPhilip J Norris
Sep 8, 2011·Transfusion·Pampee P Young, Bryan A Cotton
Aug 13, 2011·Transfusion·Philip C SpinellaJohn B Holcomb
Aug 21, 2013·Seminars in Hematology·Pierre NoelBhavesh Patel
Apr 3, 2015·Vox Sanguinis·R Cardigan, L Green
Apr 24, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Colleen S KraftUNKNOWN Nebraska Biocontainment Unit and the Emory Serious Communicable Diseases Unit
Apr 23, 2016·Transfusion·Albert Farrugia, Douglas Starr
Apr 23, 2016·Transfusion·Anthony E PusateriAndrew P Cap
Sep 19, 2016·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·F Dufour-GaumeA Sailliol
Sep 9, 2016·Acta Anaesthesiologica Scandinavica·E PesonenP K Suominen
Apr 11, 2017·Transfusion·Jessica C Cardenas, John B Holcomb
Oct 19, 2016·Shock·Justin J J WatsonMartin A Schreiber
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Yann DanielChristophe Martinaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.