Protective effects of galantamine against Abeta-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress

Neurochemistry International
Xiaoyu LiuXiaoxiang Zheng

Abstract

Amyloid beta (Abeta) is considered to be responsible for the pathogenesis of Alzheimer's disease (AD). Mitochondrial and ER apoptotic pathways are considered to be involved in this process. Galantamine is an acetylcholinesterase (AChE) inhibitor widely used for patients with AD. In this study, we investigated the neuroprotective effects of galantamine on Abeta(25-35)-induced apoptosis in PC12 cells and the underlying mechanisms. Exposure of PC12 cells to 20 microM Abeta(25-35) caused significant cell viability loss and apoptosis, Abeta aggregation, mitochondrial and ER morphological changes, as well as mitochondrial membrane potential dissipation, reactive oxygen species (ROS) production, intracellular calcium elevation, and cytochrome c release from mitochondria. Pretreatment with 10 microM galantamine for 24 h prior to Abeta(25-35) exposure significantly reduced Abeta(25-35)-induced apoptosis not only by preventing Abeta aggregation, mitochondrial and ER morphological changes, mitochondrial membrane potential dissipation, ROS production, intracellular calcium elevation, and cytochrome c release, but also via reversing Bcl-2/Bax ratio and suppressing the activity of GADD153, Grp78/94, caspase-9, caspase-12, and caspase-3. All ...Continue Reading

References

Aug 1, 1997·Trends in Biochemical Sciences·D W Nicholson, N A Thornberry
Jun 12, 2002·The Journal of Biological Chemistry·Karie N DahlgrenMary Jo LaDu
Sep 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simona CapsoniAntonino Cattaneo
Apr 10, 2003·Free Radical Biology & Medicine·Jung-Hee Jang, Young-Joon Surh
Jan 28, 2004·Free Radical Biology & Medicine·Haiyan ZengBaolu Zhao
May 4, 2004·The Journal of Pharmacology and Experimental Therapeutics·Shigeki MoriguchiToshio Narahashi
Jan 11, 2005·Brain Research Bulletin·Hugo Geerts
Jun 15, 2006·Alzheimer Disease and Associated Disorders·Akinori Akaike
Sep 26, 2006·European Journal of Pharmacology·Yuki Takada-TakatoriAkinori Akaike
Jan 2, 2007·Chemico-biological Interactions·Silvia C LenzkenMarco Racchi
Mar 3, 2007·Psychosomatics·Benjamin JohnsonShree Bhalerao
May 29, 2007·The Journal of Pharmacology and Experimental Therapeutics·Silvia LorrioManuela G López
Nov 16, 2007·The European Journal of Neuroscience·Yi YangXiaoxiang Zheng
Feb 19, 2009·The European Journal of Neuroscience·Joana B MeloPaula Agostinho
Mar 3, 2009·Biological & Pharmaceutical Bulletin·Yuki Takada-TakatoriAkinori Akaike
Apr 8, 2009·Current Neurology and Neuroscience Reports·Bingwei Lu

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Citations

Mar 29, 2013·International Journal of Pharmaceutics·Maluta S MufamadiViness Pillay
Jun 7, 2011·Drugs & Aging·Melanie-Jayne R Howes, Elaine Perry
Dec 25, 2012·International Journal of Molecular Sciences·Bidur BhandaryHan-Jung Chae
Jun 3, 2014·Biological & Pharmaceutical Bulletin·Sunyoung KimJungsook Cho
Oct 23, 2013·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Emanuel A AdewusiVanessa Steenkamp
Oct 14, 2014·Neurological Research·Han-Chang HuangZhao-Feng Jiang
Nov 5, 2016·Neurotoxicology·Willian O CastilloCatarina S Takahashi
Mar 8, 2016·International Journal of Molecular Sciences·Hafiz Maher Ali ZeeshanHan-Jung Chae
Sep 6, 2018·International Journal of Molecular Sciences·Julia RelatM Victòria Clos
Nov 7, 2019·Journal of Neurochemistry·Trevor W Stone
Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Caiyun ZhangXia Li
Feb 28, 2018·Frontiers in Aging Neuroscience·Devesh TewariAtanas G Atanasov
May 31, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Barnabas Wilson, Kannoth Mukundan Geetha

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