Protective effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on liver injury in rats

The American Journal of Chinese Medicine
Hsin-Fang ChangJane C-J Chao

Abstract

This study investigated the effects of the combined extracts of Ginkgo biloba, Panax ginseng, and Schizandra chinensis at different doses on hepatic antioxidant status and fibrosis in rats with carbon tetrachloride (CCl4)-induced liver injury. Male Sprague-Dawley rats (n = 8-12 per group) were divided into the control, CCl4, CCl4 + silymarin (0.35%), CCl4 + low-dose herbal extract (0.24% of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract at 1:1:1; LE), and CCl4 + high-dose herbal extract (1.20% of the same herbal extract; HE) groups. Silymarin or herbal extract was orally given to rats a week before chronic intraperitoneal injection with CCl4 for 6 weeks. The pathological results showed that herbal extract suppressed hepatic bile duct proliferation, and low-dose herbal extract inhibited liver fibrosis. Hepatic superoxide dismutase (SOD) activity was lower in the CCl4 group, but there was no difference in the silymarin or herbal extract treated groups compared to the control group. Hepatic catalase activity and the ratio of reduced to oxidized glutathione were significantly higher (p < 0.05) in the HE group than those in the CCl4 group. Silymarin and herbal extract reversed the impaired hepatic total antioxidant s...Continue Reading

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Citations

Oct 28, 2009·Journal of Medicinal Food·Caroline DaniJoão Antonio Pegas Henriques
Dec 4, 2008·The American Journal of Chinese Medicine·Elaine LinChun-Su Yuan
Jan 25, 2014·Journal of Medicinal Food·Hyoung Joon ParkJae-Hyeon Cho
Sep 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Nguyen Huu TungYukihiro Shoyama
Nov 15, 2011·Toxicology and Applied Pharmacology·Eman M MantawyEbtehal El-Demerdash
Feb 19, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ezzeldeen S El DensharyMosaad A Abdel-Wahhab
Jul 22, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Changjiang XuWilliam Jia
Feb 4, 2010·The American Journal of Chinese Medicine·Shu-Ju WuJane C-J Chao
Jan 15, 2017·BMC Complementary and Alternative Medicine·Mohamed M HafezShakir Dekhal Alsharari
Jun 2, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Memy H Hassan, Mohamed M Ghobara
Jun 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed SekkienAbdel Nasser Singab
Sep 21, 2017·Medicines·Tae-Woo Kim
Feb 6, 2013·International Journal of Molecular Medicine·In Sik HwangDae Youn Hwang
Mar 28, 2020·Journal of Food Biochemistry·Mabrouk A Abo-ZaidAhmed H Ismail

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