Abstract
Inflammation plays an important role in acute lung injury (ALI). Hesperetin (HES), a natural flavanone and an aglycone of hesperidin, has established potent anti-inflammatory activity. The aim of this study was to evaluate the potential protective effect of HES on lipopolysaccharide (LPS)-induced ALI in mice and to illuminate its possible directly target. Results indicated that HES pretreatment significantly attenuated LPS-induced pulmonary pathological injury, total protein concentration, markedly decreased the number of neutrophils and the levels of inflammatory cytokines, TNF-α and IL-6, in ALI model in vivo and in vitro. Meanwhile, pretreatment with HES dramatically reduced myeloperoxidase (MPO) activity in LPS-induced ALI mice. Additionally, using molecular docking and co-immunoprecipitation assay, HES showed a directly bind with myeloid differentiation 2 (MD2), in which HES could inhibit MAPK activation, regulate IκB degradation, block the interaction MD2 and its co-receptor Toll-like receptor 4 (TLR4). Taken together, HES showed a significantly protective effect against LPS-induced ALI, which might be associated with MD2 protein. These results attested HES worthy of further progress into an adjunctive potential drug for ...Continue Reading
References
Jul 5, 2003·Physiological Reviews·Dean Sheppard
Feb 12, 2004·Journal of Internal Medicine·H WangK J Tracey
Dec 2, 2004·Blood·Christopher C SillimanLynn K Boshkov
Oct 26, 2005·Nature Medicine·Dianhua JiangPaul W Noble
Jun 16, 2007·Science·Umeharu OhtoYoshinori Satow
Jul 19, 2008·American Journal of Respiratory and Critical Care Medicine·Mark M WurfelThomas R Martin
Oct 14, 2008·American Journal of Respiratory and Critical Care Medicine·Lynne A MurrayCory M Hogaboam
Mar 6, 2010·Nature·Qin ZhangCarl J Hauser
Apr 7, 2010·Expert Opinion on Investigational Drugs·Ken-ichiro Inoue, Hirohisa Takano
May 10, 2011·Cardiovascular Toxicology·P P TrivediG B Jena
Jan 10, 2012·Journal of Agricultural and Food Chemistry·Sam-Long HwangGow-Chin Yen
Feb 22, 2012·Biochemical and Biophysical Research Communications·Lanan Wassy SoromouXuming Deng
Jan 15, 2013·Toxicology·Fangfang LiuChen Wang
Feb 5, 2013·Microvascular Research·Binit KumarKumar Abhiram Jha
May 7, 2013·Lancet·Alexander P J Vlaar, Nicole P Juffermans
Sep 3, 2013·Bioorganic & Medicinal Chemistry Letters·Hongtao Zhao, Amedeo Caflisch
Jun 16, 2015·British Journal of Pharmacology·Yi WangGuang Liang
Nov 28, 2015·European Journal of Pharmacology·Hongzhong MaSuchun Ding
Jul 9, 2016·Drug Design, Development and Therapy·Xiangting GeGuang Liang
Nov 3, 2016·Respiratory Care·Jan MácaPavel Ševčík
Jan 4, 2017·Nature Communications·Yi WangGuang Liang
Mar 18, 2017·American Journal of Respiratory and Critical Care Medicine·John G Laffey, Michael A Matthay
May 2, 2017·Archives of Physiology and Biochemistry·Sukumar BabukumarMadhavan Ramados Nirmal
Aug 15, 2017·Critical Care Medicine·Marina García-de-AciluOriol Roca
Dec 16, 2017·British Journal of Pharmacology·Yali ZhangGuang Liang
Dec 23, 2017·Nature Communications·So Yeon KimWon-Il Jeong
Jan 10, 2018·Cellular and Molecular Life Sciences : CMLS·Anshika TandonJimut Kanti Ghosh
Jan 14, 2018·Drug Discovery Today·Lingfeng ChenGuang Liang
Feb 27, 2018·Kidney International·Naila Rabbani, Paul J Thornalley
Mar 24, 2018·Inflammation·Xue-Feng WangHui-Fang Tang
Jun 22, 2018·Scientific Reports·Nadine BiesemannCarsten Strübing
Sep 5, 2018·Life Sciences·Alireza SamieMehrdad Roghani
Citations
Mar 12, 2020·Food & Function·Zeng LinJun Pan
Dec 6, 2019·Archives of Pharmacal Research·Naigang WangXunchao Liu
Jul 31, 2020·Antibiotics·Suresh MickymarayAnand Paramasivam
Oct 30, 2019·Molecular Diversity·Adam HermawanRohmad Yudi Utomo
Apr 23, 2020·Antioxidants & Redox Signaling·Dario C Ramirez, Sandra E Gomez Mejiba
Aug 8, 2020·Journal of Biochemical and Molecular Toxicology·Junying DongCan Chang
Jan 15, 2020·Current Neuropharmacology·Miryam Nava Catorce, Goar Gevorkian
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lucas Amaral-MachadoEryvaldo S T Egito
Apr 1, 2021·Phytotherapy Research : PTR·Abhishek GourUtpal Nandi
May 8, 2021·Journal of Complementary & Integrative Medicine·Niloofar HonariMehran Hosseini
Jun 1, 2021·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Moza Mohamed AlzaabiSameh S M Soliman
Aug 28, 2021·Biomolecules·Naiara Naiana DejaniDamião Pergentino de Sousa
Sep 8, 2021·Frontiers in Immunology·Shih-Wei WuKun-Lun Huang
Nov 6, 2021·Nutrition and Cancer·Carolina SousaMafalda Videira