Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury by targeting MD2

European Journal of Pharmacology
Jinyan YeCaicun Zhou

Abstract

Inflammation plays an important role in acute lung injury (ALI). Hesperetin (HES), a natural flavanone and an aglycone of hesperidin, has established potent anti-inflammatory activity. The aim of this study was to evaluate the potential protective effect of HES on lipopolysaccharide (LPS)-induced ALI in mice and to illuminate its possible directly target. Results indicated that HES pretreatment significantly attenuated LPS-induced pulmonary pathological injury, total protein concentration, markedly decreased the number of neutrophils and the levels of inflammatory cytokines, TNF-α and IL-6, in ALI model in vivo and in vitro. Meanwhile, pretreatment with HES dramatically reduced myeloperoxidase (MPO) activity in LPS-induced ALI mice. Additionally, using molecular docking and co-immunoprecipitation assay, HES showed a directly bind with myeloid differentiation 2 (MD2), in which HES could inhibit MAPK activation, regulate IκB degradation, block the interaction MD2 and its co-receptor Toll-like receptor 4 (TLR4). Taken together, HES showed a significantly protective effect against LPS-induced ALI, which might be associated with MD2 protein. These results attested HES worthy of further progress into an adjunctive potential drug for ...Continue Reading

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Citations

Aug 8, 2020·Journal of Biochemical and Molecular Toxicology·Junying DongCan Chang
Jan 15, 2020·Current Neuropharmacology·Miryam Nava Catorce, Goar Gevorkian
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lucas Amaral-MachadoEryvaldo S T Egito
Apr 1, 2021·Phytotherapy Research : PTR·Abhishek GourUtpal Nandi
May 8, 2021·Journal of Complementary & Integrative Medicine·Niloofar HonariMehran Hosseini
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Aug 28, 2021·Biomolecules·Naiara Naiana DejaniDamião Pergentino de Sousa
Sep 8, 2021·Frontiers in Immunology·Shih-Wei WuKun-Lun Huang

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