Abstract
BACKGROUND Fibrotic change is one of the important reasons for the poor prognosis of patients with acute respiratory distress syndrome (ARDS). The present study investigated the effects of hydrogen-rich saline, a selective hydroxyl radical scavenger, on lipopolysaccharide (LPS)-induced pulmonary fibrosis. MATERIAL AND METHODS Male ICR mice were divided randomly into 5 groups: Control, LPS-treated plus vehicle treatment, and LPS-treated plus hydrogen-rich saline (2.5, 5, or 10 ml/kg) treatment. Twenty-eight days later, fibrosis was assessed by determination of collagen deposition, hydroxyproline, and type I collagen levels. Development of epithelial-to-mesenchymal transition (EMT) was identified by examining protein expressions of E-cadherin and α-smooth muscle actin (α-SMA). Transforming growth factor (TGF)-β1 content, total antioxidant capacity (T-AOC), malondialdehyde (MDA) content, catalase (CAT), and superoxide dismutase (SOD) activity were determined. RESULTS Mice exhibited increases in collagen deposition, hydroxyproline, type I collagen contents, and TGF-β1 production in lung tissues after LPS treatment. LPS-induced lung fibrosis was associated with increased expression of α-SMA, as well as decreased expression of E-cadh...Continue Reading
References
Oct 6, 2000·Clinics in Chest Medicine·J F Tomashefski
Jul 30, 2003·Free Radical Biology & Medicine·R C J LangenE F M Wouters
Aug 5, 2003·The Journal of Biological Chemistry·Rachel G KhadarooOri D Rotstein
Jul 17, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brigham C Willis, Zea Borok
Dec 10, 2008·Brain Research·Jianmei CaiXuejun Sun
Mar 3, 2009·Biochemical and Biophysical Research Communications·Yan-Fei MaoXue-Jun Sun
Mar 10, 2009·Toxicology and Applied Pharmacology·Shufan QiAalt Bast
May 29, 2009·Innate Immunity·Hui LiZhibin Yao
Aug 25, 2009·Nature Medicine·Louise HeckerVictor J Thannickal
Nov 12, 2009·Antioxidants & Redox Signaling·Stefania CannitoMaurizio Parola
Dec 29, 2009·European Journal of Pharmacology·Tao YangXiao-Yan Zhu
Jan 22, 2010·Shock·Wei WeiZhaofan Xia
Aug 10, 2010·The Journal of Surgical Research·Lijin ZhaoShuguang Wang
Nov 9, 2010·Annual Review of Physiology·Harold A Chapman
Nov 12, 2010·The Journal of Surgical Research·Qiang SunXuejun Sun
Dec 15, 2010·Journal of Hepatology·HanYong SunHongYang Wang
Mar 26, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·Yong FangMin Yao
Jul 9, 2011·Current Pharmaceutical Design·Shigeo Ohta
Feb 22, 2012·Innate Immunity·Man-Chin ChenChe-Hsin Lee
Apr 17, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daisuke KawaiKazuhide Yamamoto
Sep 4, 2012·BMC Medicine·Ying-Ying JingLi-Xin Wei
Jan 5, 2013·The EMBO Journal·David BalliTanya V Kalin
Mar 5, 2013·European Respiratory Review : an Official Journal of the European Respiratory Society·Vincent Cottin
Mar 23, 2013·The European Respiratory Journal·Ellen L BurnhamGregory P Downey
May 21, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yukinori KoyamaShinji Uemoto
Jul 23, 2013·International Immunopharmacology·Bo XuDa-peng Jiang
Dec 18, 2013·Biochemical and Biophysical Research Communications·Fumihiro IshikawaMotoko Shibanuma
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Samy LamouilleRik Derynck
Sep 23, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yun-Qian ZhangLai Jiang
Citations
Apr 6, 2018·Molecular Medicine Reports·Feng ZhangXiao-Neng Mo
Sep 24, 2020·Oxidative Medicine and Cellular Longevity·Mengling YangMingyi Zhao
Nov 30, 2018·Immunopharmacology and Immunotoxicology·Ali-Mohammad RoustaMehrdad Roghani
Aug 24, 2019·Frontiers in Pharmacology·Sihua TanYaxing Zhang
Jul 6, 2019·Bioscience Reports·Huaping HuangXi Li
Feb 28, 2021·The Journal of Surgical Research·Hiroshi MatsuuraTakeshi Shimazu
Apr 2, 2021·Environmental Toxicology·Junyan YanBaowei Hu
Mar 9, 2018·European Journal of Pharmacology·Mohammad-Reza Khajevand-KhazaeiMehrdad Roghani
Oct 19, 2021·Frontiers in Pharmacology·De-Wei ZhuYun-Hui Shen
Feb 23, 2019·Life Sciences·Takahiro SakaiShinichi Hatta