Protective effects of IL4-589T and RANTES-28G on HIV-1 disease progression in infected Thai females

AIDS
Nuanjun WichukchindaT Shioda

Abstract

To evaluate the effect of polymorphisms in interleukin-4 (IL4) and RANTES promoters on disease progression in HIV-1 infected Thais. Antiretroviral (ARV) drug-free HIV-1 infected females from the prospective cohort. A total of 246 DNA samples were genotyped for IL4 and RANTES promoter polymorphisms by PCR-RFLP. Associations of genotype with HIV-1 disease progression were assessed with respect to baseline clinical data including plasma HIV-1 load, CD4 cell counts, and proportion of symptomatic/AIDS, and survival status during 3 years of follow-up. Patients with homozygous IL4-589T allele showed a significantly lower HIV-1 viral load (P = 0.005) and a higher CD4 cell count (P = 0.003) than the other patients with heterozygous IL4-589C/T or homozygous IL4-589C allele. Kaplan-Meier analysis demonstrated an apparent but insignificant trend towards better survival in homozygous IL4-589T patients. On the other hand, patients with RANTES-28G allele showed a significantly better survival while those with RANTES In1.1C allele without RANTES-28G showed a significantly poorer survival compared with those who did not possess either RANTES In1.1C or RANTES-28G (P = 0.02), although those polymorphisms only weakly associated with baseline viral...Continue Reading

References

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Citations

Dec 28, 2007·AIDS Research and Human Retroviruses·Suda LouisirirotchanakulYutaka Takebe
Jul 27, 2007·Retrovirology·Juan Lama, Vicente Planelles
Aug 28, 2012·Retrovirology·Daniëlle van ManenHanneke Schuitemaker
Jul 27, 2006·International Journal of Hematology·Tatsuo Shioda, Emi E Nakayama
Feb 9, 2012·The Indian Journal of Medical Research·Gaurav SharmaNarinder Mehra
Jan 17, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nuanjun WichukchindaTatsuo Shioda
Jul 8, 2011·Current Opinion in HIV and AIDS·Magdalena E SobieszczykM Juliana McElrath
Sep 29, 2011·Tuberculosis·S RaghavanP Selvaraj
Feb 13, 2010·Trends in Genetics : TIG·Ping An, Cheryl A Winkler
Dec 20, 2008·Journal of Internal Medicine·L PiacentiniM Clerici
Jun 4, 2010·International Journal of Immunogenetics·D A KatzC Farquhar
Aug 16, 2018·The Journal of Gene Medicine·Swati Ahir-BistJayanti Mania-Pramanik
Jun 30, 2011·Molecular Biology Reports·Ranbiden Chandera SobtiAjay Wanch
Nov 9, 2016·Disease Markers·Shem P M MutuiriSamoel A Khamadi

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