Protective Effects of Intraoperative Nerve Monitoring (IONM) for Recurrent Laryngeal Nerve Injury in Thyroidectomy: Meta-analysis

Scientific Reports
Binglong Bai, Wuzhen Chen

Abstract

Recurrent laryngeal nerve (RLN) injury is an intractable complication of thyroidectomy. Intraoperative nerve monitoring (IONM) was designed to prevent RLN injury. However, the results concerning the protective effect of IONM on RLN injury are still controversial. We searched all eligible databases from 1980 to 2017. Meta-analysis was performed to evaluate the effect of IONM on RLN injury. Sensitivity analysis was also conducted to check the stability of our results. There were 34 studies included in the analysis. Overall analysis found a significant decrease in total injury (RR = 0.68, 95%CI: 0.55 to 0.83), transient injury (RR = 0.71, 95%CI: 0.57 to 0.88), and permanent injury (RD = -0.0026, 95%CI: -0.0039 to -0.0012) with IONM. Subgroup analysis found IONM played a preventive role of total, transient and permanent injury in patients undergoing bilateral thyroidectomy. IONM also reduced the incidence of total and transient injury for malignancy cases. Operations with IONM were associated with fewer total and transient RLN injuries in operation volume < 300 NARs per year and fewer total and permanent RLN injuries in operation volume ≥ 300 NARs per year. The application of IONM could reduce the RLN injury of thyroidectomy. Parti...Continue Reading

References

Jan 1, 1987·Epidemiologic Reviews·S Greenland
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 4, 2002·American Journal of Surgery·Oliver ThomuschHenning Dralle
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matt L RobertsonJeff Welge
Aug 17, 2005·Journal of Voice : Official Journal of the Voice Foundation·Robert L Witt
May 25, 2007·Archives of Otolaryngology--head & Neck Surgery·Maisie Shindo, Neil N Chheda
Oct 10, 2007·São Paulo Medical Journal = Revista Paulista De Medicina·Irene de Pedro NettoLuiz Paulo Kowalski
Dec 19, 2007·Archives of Otolaryngology--head & Neck Surgery·David J TerrisEdward Chin
Sep 23, 2008·Surgical Endoscopy·Gianlorenzo DionigiRenzo Dionigi
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jul 6, 2010·International Journal of Surgery·Serkan SarıSelcuk Ozarmagan
Jan 27, 2011·World Journal of Surgery·Antoine DuclosJean-Louis Peix
Feb 2, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Emmanuel ProkopakisGeorge Velegrakis
Jun 14, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sujana S ChandrasekharUNKNOWN American Academy of Otolaryngology-Head and Neck Surgery
Sep 11, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shixing ZhengJinnian He
May 28, 2014·International Journal of Surgery·Massimo De FalcoUmberto Parmeggiani
Aug 28, 2014·Journal of the American College of Surgeons·Thomas K ChungMary T Hawn
Nov 11, 2014·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Sophie J R de DanschutterHans K S Nuytinck
May 31, 2015·Acta otorrinolaringológica española·José Luis Pardal-Refoyo, Carlos Ochoa-Sangrador
Dec 23, 2015·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Qiuping XieYong Wang
Dec 29, 2015·International Journal of Surgery·Pietro Giorgio CalòAngelo Nicolosi
Jan 29, 2016·World Journal of Surgery·Gianlorenzo DionigiFeng-Yu Chiang
Feb 19, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Hu HeiYongping Song
Jul 15, 2016·International Journal of Endocrinology·Bin LvQing-Dong Zeng
Jul 28, 2016·The Journal of Surgical Research·Brian C Brajcich, Christopher R McHenry
Oct 22, 2016·JAMA Otolaryngology-- Head & Neck Surgery·Ioannis VasileiadisGregory Kouraklis
Dec 31, 2016·International Journal of Surgery·Kai Pun WongBrian Hung Hin Lang
Jan 29, 2017·International Journal of Surgery·Shuwen YangYu Wang

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Citations

Apr 12, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Alvaro SanabriaUNKNOWN International Head and Neck Scientific Group
Jun 21, 2019·Annals of the Royal College of Surgeons of England·E O GürY Kumkumoglu
Nov 13, 2020·Clinical and Experimental Otorhinolaryngology·Sung-Chan Shin, Byung-Joo Lee
Feb 23, 2021·KI Reports·Gabrielle K Steinl, Jennifer H Kuo
Apr 15, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Serkan KaraisliMehmet Haciyanli
May 4, 2021·The Journal of Surgical Research·Eugenio GarofaloFederico Longhini

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