Protective effects of kappa-ca3000+CP against ultraviolet-induced damage in HaCaT and MEF cells

Journal of Photochemistry and Photobiology. B, Biology
Shu-Wen RenHua-Shi Guan

Abstract

In this study, the complex kappa-ca3000+CP combined collagen peptide with kappa-carrageenan oligosaccharide was tested for its ability to moderate UV-induced damage and investigated for its protective mechanism against UV radiation. Human keratinocytes (HaCaT) and mouse embryonic fibroblasts (MEF) were used to monitor the effects of kappa-ca3000+CP on cell viability, apoptosis, level of collagen I and MMP-1, MAPKs activation and intracellular ROS production after UV-irradiation. The results indicated that application of the kappa-ca3000+CP (100 microg/ml) could significantly attenuate UV-induced HaCaT and MEF death, as well as inhibit the UV-induced apoptosis of HaCaT cells. The decreased collagen I synthesis and the increased MMP-1 expression of MEF by UV radiation were almost restored back to normal level after treatment with kappa-ca3000+CP. Moreover, kappa-ca3000+CP could significantly suppress UV-induced MAPKs activation and intracellular ROS production. Taken together, these results showed that antioxidant property of kappa-ca3000+CP can effectively attenuate UV-caused cell damage and skin photoaging by suppressing cell apoptosis and expression of MMP-1 through the MAPKs signaling pathways. Thus, kappa-ca3000+CP has poten...Continue Reading

References

Nov 14, 1997·The New England Journal of Medicine·G J FisherJ J Voorhees
May 8, 1999·The Journal of Investigative Dermatology·D PeusM R Pittelkow
Feb 28, 2002·Carbohydrate Research·Guangli YuRobert J Linhardt
Nov 20, 2002·Archives of Dermatology·Gary J FisherJohn J Voorhees
Jan 28, 2003·Journal of Photochemistry and Photobiology. B, Biology·Ying MuGuimin Luo
Jun 25, 2003·Toxicology·M IchihashiT Horikawa
May 18, 2005·Journal of Photochemistry and Photobiology. B, Biology·Helga MerwaldFranz Trautinger
Jun 21, 2005·Biochimica Et Biophysica Acta·Zerihun AssefaPatrizia Agostinis
Dec 20, 2005·Journal of Dermatological Science·Muriel IsoirMarc Benderitter
Jun 20, 2006·Journal of the American Academy of Dermatology·Jessica H RabeDaniel N Sauder
Aug 11, 2007·Journal of Dermatological Science·Alena SvobodováJitka Vostálová
Jun 25, 2008·Journal of Hazardous Materials·Siva Kumar NadavalaKrishnaiah Abburi
Jan 20, 2009·Journal of Colloid and Interface Science·Yinyan ZhaoMichael T Harris
Sep 26, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jheng-Hua HuangChi-Feng Hung
Feb 18, 2010·Journal of Bioscience and Bioengineering·Hyun-kyung ChoiChang Seo Park

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Citations

Jul 28, 2020·Pharmaceutics·Ioannis AnestopoulosMihalis I Panayiotidis
Nov 25, 2018·Marine Drugs·Ji Hye KimNam Joo Kang

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