Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats

The World Journal of Men's Health
Woong Jin BaeSae Woong Kim

Abstract

We investigated the protective effects of the herbal formulation KH-204 in the bladder of androgen-deprived rats. Male rats aged eight weeks were randomly divided into four groups, containing eight rats each: sham operation only (normal control group), androgen-deprived only (androgen-deprived control group), and androgen-deprived followed by treatment with 200 mg/kg or 400 mg/kg of KH-204. After 0.5 mg/kg of leuprorelin was subcutaneously injected in the androgen-deprived groups, the oral administration of either distilled water in the two control groups or KH-204 in the treatment group was continued for four weeks. Serum testosterone levels, RhoGEF levels, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, oxidative stress, and histologic changes were evaluated after treatment. Treatment with the herbal formulation KH-204 (1) increased serum testosterone levels; (2) restored the expression of RhoGEFs, endothelial NO synthase, and neuronal NO synthase; (3) increased the expression of superoxide dismutase; and (4) decreased bladder fibrosis. Our results suggest that the positive effects of KH-204 on the urinary bladder may be attributed to its antioxidant effects or to an elevation in NO-cGMP activity.

References

Mar 1, 1988·The Journal of Urology·A L ChunA J Wein
Jan 1, 1994·Urological Research·I EhrénN P Wiklund
Feb 1, 1993·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·S Takyu
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P LluelD J Martin
Jan 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alvin M Matsumoto
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Henry A FeldmanJohn B McKinlay
Mar 15, 2002·Obstetrics and Gynecology Clinics of North America·Blake Cady
Jan 10, 2004·Advances in Experimental Medicine and Biology·Wulf Dröge
Nov 11, 2005·International Journal of Impotence Research·A Barqawi, E D Crawford
Feb 14, 2008·The Journal of Clinical Endocrinology and Metabolism·Frederick C W WuUNKNOWN European Male Aging Study Group
Jun 24, 2008·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Wisuit Pradidarcheep
Jul 3, 2008·World Journal of Urology·Aksam A YassinLouis J G Gooren
Sep 3, 2008·European Urology·Christina WangUNKNOWN American Society of Andrology
May 19, 2010·Current Urology Reports·Alex Gomelsky, Roger R Dmochowski
Jun 18, 2010·The New England Journal of Medicine·Frederick C W WuUNKNOWN EMAS Group
Nov 17, 2011·Korean journal of urology·Kazuyoshi Shigehara, Mikio Namiki
Oct 2, 2014·BMC Complementary and Alternative Medicine·Woong Jin BaeSae Woong Kim

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Citations

Jan 9, 2017·The World Journal of Men's Health·Hyong Woo MoonSae Woong Kim

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Methods Mentioned

BETA
androgen replacement therapy
Protein Assay
electrophoresis
enzyme-linked immunosorbent assay
ELISA
Assay

Software Mentioned

SPSS
Image Pro Plus

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