Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats

Andrologia
Ebenezer O FarombiA S Eboh

Abstract

This study evaluated the effects of kolaviron, a biflavonoid from Garcinia kola seed, and quercetin on cadmium-induced reproductive toxicity in rats. Adult male rats were administered with either cadmium (15 mg kg(-1)) alone or in combination with kolaviron (200 mg kg(-1)) or quercetin (10 mg kg(-1)) daily for 5 days. Cadmium-treated rats showed (P < 0.05) decrease in the body weight gain, testis and epididymis weights. However, upon co-administration of kolaviron or quercetin, these changes were significantly reversed in cadmium-treated rats. Also, administration of kolaviron or quercetin significantly prevented cadmium-mediated decrease in sperm motility and epididymal sperm concentration and reversed the increased level of sperm abnormality to near control. In testes and sperm, cadmium treatment resulted in significant decrease in the activities of superoxide dismutase, catalase and glutathione peroxidase, whereas it increased glutathione S-transferase activity as well as hydrogen peroxide and malondialdehyde levels. While plasma levels of triiodothyronine and tetraiodothyronine remained unaffected, the levels of testosterone, luteinising hormone and follicle stimulating hormone were decreased in cadmium-treated rats. Cadmiu...Continue Reading

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Citations

Apr 30, 2013·Biological Trace Element Research·Amr A FouadIyad Jresat
Sep 24, 2013·Environmental Toxicology and Pharmacology·Isaac A AdedaraEbenezer O Farombi
Oct 14, 2014·Journal of Toxicology·Ebenezer Tunde Olayinka, Ayokanmi Ore
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