Protective effects of Labisia pumila var. alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Roza DianitaJuriyati Jalil

Abstract

The study was designed to evaluate the cardioprotective effects of the standardized aqueous and 80% ethanol extracts of Labisia pumila var. alata (LPva) in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. The extracts were administered to Wistar rats orally for 28 days with three doses (100, 200 and 400 mg/kg of body weight) prior to ISO (85 mg/kg)-induced MI in two doses on day 29 and 30. The sera and hearts were collected for biochemical and histopathological analysis after the rats were sacrificed 48 h after the first induction. The main components of the extracts, gallic acid, alkylresorcinols and flavonoids were identified and quantitatively analyzed in the extracts by using a validated reversed phase HPLC method. The extracts showed significant protective effects as pretreated rats showed a significant dose-dependent decrease (p < 0.05) in cardiac enzyme activities, i.e., cardiac troponin I (cTnI), creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase (LDH), alanine transaminase (ALT) and aspartate transaminase (AST), when compared with ISO-control rats. There were significant rises (p < 0.05) in the activity of oxidase enzymes, i.e., glutathione peroxide (GPx), catalase (CAT) and superoxide dismutase...Continue Reading

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Citations

Jun 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Roza DianitaAthirah Zawani Amran
May 13, 2014·Biochemical and Biophysical Research Communications·Li LiuTeng Zhang
Jul 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haryati Ahmad HairiAhmad Nazrun Shuid
Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Małgorzata Kiełczykowska, Irena Musik

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Methods Mentioned

BETA
NMR
enzyme-linked immunosorbent assay

Software Mentioned

SPSS Statistics

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