Protective effects of melatonin against carbon tetrachloride-induced hepatotoxicity in rats: a light microscopic and biochemical study

Cell Biochemistry and Function
Ilter KuşMustafa Sarsilmaz

Abstract

The aim of this study was to examine the protective effects of melatonin against CCl4-induced hepatotoxicity in the rat. Twenty-four male Wistar rats were divided into three groups. Group I was used as a control. Rats in group II were injected every other day with CCl4 for 1 month, whereas rats in group III were injected every other day with CCl4 and melatonin for 1 month. At the end of the experiment, all animals were killed by decapitation and blood samples were obtained. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total and conjugated bilirubin levels were determined. For histopathological evaluation, livers of all rats were removed and processed for light microscopy. All serum biochemical parameters were significantly higher in animals treated with CCl4 than in the controls. When rats injected with CCl4 were treated with melatonin, significantly reduced elevations in serum biochemical parameters were found. In liver sections of the CCl4-injected group, necrosis, fibrosis, mononuclear cell infiltration, haemorrhage, fatty degeneration and formation of regenerative nodules were observed. Additionally, apoptotic figures, microvesicular steatosis and hydropic degeneration ...Continue Reading

References

Jul 1, 1978·Toxicology and Applied Pharmacology·N Stacey, B G Priestly
Jan 1, 1992·Endocrine Research·J M Guerrero, R J Reiter
Jan 1, 1989·Pharmacology & Therapeutics·R O RecknagelR L Waller
Jan 1, 1989·Toxicologic Pathology·P R KodavantiH M Mehendale
Jan 1, 1987·Annual Review of Pharmacology and Toxicology·G F KalfR Snyder
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MackinnonP Hall
Jan 1, 1994·Life Sciences·C PieriF Marcheselli
Dec 1, 1995·Free Radical Biology & Medicine·E SewerynekR J Reiter
Dec 7, 1995·European Journal of Pharmacology·E SewerynekA Lewinski
Apr 26, 1996·Biochemical Pharmacology·D MelchiorriG Nisticò
Jan 1, 1997·Free Radical Biology & Medicine·M A LivreaM Morreale
Mar 13, 1998·Life Sciences·B LongoniP L Marchiafava
Aug 7, 1998·Journal of Pineal Research·P StasicaJ M Rosiak
Dec 5, 1998·Biochimica Et Biophysica Acta·L Y ZangV Vallyathan
Jan 27, 1999·Biochemical and Biophysical Research Communications·D X TanA M Shepherd
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KilicT Dalkara
Dec 10, 1999·Cell Biochemistry and Function·M NaziroğluH Yekeler

❮ Previous
Next ❯

Citations

Dec 25, 2010·World Journal of Gastroenterology : WJG·Alexander M Mathes
Jun 14, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ayhan Atasever, Duygu Yaman
Jan 26, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eduardo Esteban-ZuberoRussel J Reiter
Dec 19, 2015·Journal of Pineal Research·Wei HuYang Yang
Dec 1, 2005·Cell Biochemistry and Function·Diogo Luiz OliveiraMariza Pires de Melo
Dec 25, 2008·Cell Biochemistry and Function·Luciana R M B MourãoMariza P de Melo
Jul 7, 2007·Journal of Pineal Research·Zehra KurcerErcument Olmez
May 16, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·N Kuloglu, M F Sönmez
Nov 18, 2015·Canadian Journal of Physiology and Pharmacology·Keywan MortezaeeIraj Ragerdi Kashani
May 13, 2015·Cell Biochemistry and Function·Elena A LapshinaIlya B Zavodnik
May 8, 2015·BioMed Research International·Ahmed H ArbabSyed Rafatullah
Dec 3, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Irene CrespoMaría J Tuñón
Feb 24, 2011·Toxicology and Industrial Health·Ufuk TasMustafa Sarsilmaz
Mar 24, 2017·International Journal of Molecular Sciences·Jiao-Jiao ZhangHua-Bin Li
Aug 23, 2008·Toxicology and Industrial Health·I ZararsizE Ozan
Oct 11, 2007·The Journal of Pharmacology and Experimental Therapeutics·Amber M MuehlmannDarragh P Devine
Sep 12, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Leonardo BaiocchiGianfranco Alpini
Jan 22, 2011·Chemical Reviews·Lan Lin, Ren Xiang Tan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.