Oct 1, 1978

Protective effects of methyl prednisolone and dimethyl sulfoxide in experimental middle cerebral artery embolectomy

Journal of Neurosurgery
R K LahaJ C Maroon

Abstract

Acute arterial embolism continues to be a major cause of stroke morbidity in children and young adults. Potential therapy modalities include medical management and/or cerebral revascularization. The canine middle cerebral artery (MCA) was embolized by means of a pliable cylinder, 8 mm long by 1.6 mm in diameter, via the internal carotid artery. Control and experimental embolectomies were performed 6 hours following embolization. The experimental animals were treated with either dimethyl sulfoxide (DMSO) or methyl prednisolone. In the control animals, the average area of infarction in the brain was 1.45 cu cm. The animals treated with methyl prednisolone (2 mg/kg) or DMSO (2 gm/kg) showed no infarction of the brain, whereas methyl prednisolone (30 mg/kg) did not prevent infarction.

  • References43
  • Citations29

References

  • References43
  • Citations29

Citations

Mentioned in this Paper

Morbidity Aspects
Arterial Embolism
Dimethyl Sulfoxide
Brain
Prednisolone
Cerebral Arterial Diseases
Body Surface Area Formula for Dogs
Posterior Choroidal Artery Infarction
Cerebral Hemisphere Structure (Body Structure)
Entire Internal Carotid Artery

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