Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
S CuzzocreaAchille P Caputi

Abstract

Oxidative stress has been suggested as a potential mechanism in the pathogenesis of lung inflammation. The pharmacological profile of n-acetylcysteine (NAC), a free radical scavenger, was evaluated in an experimental model of lung injury (carrageenan-induced pleurisy). Injection of carrageenan into the pleural cavity of rats elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity that contained many neutrophils (PMNs), an infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate, tumor necrosis factor alpha, and interleukin 1beta. All parameters of inflammation were attenuated by NAC treatment. Furthermore, carrageenan induced an up-regulation of the adhesion molecules ICAM-1 and P-selectin, as well as nitrotyrosine and poly (ADP-ribose) synthetase (PARS), as determined by immunohistochemical analysis of lung tissues. The degree of staining for the ICAM-1, P-selectin, nitrotyrosine, and PARS was reduced by NAC. In vivo NAC treatment significantly reduced peroxynitrite formation as measured by the oxidation of the fluorescent dihydrorhodamine-123, prevented the appearance of DNA damage, an decrease in mitochondrial respiration, an...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Mar 1, 1992·American Journal of Respiratory Cell and Molecular Biology·E M DrostW MacNee
Nov 1, 1992·Archives of Biochemistry and Biophysics·H IschiropoulosJ S Beckman
Jun 27, 1991·The New England Journal of Medicine·P M HarrisonR Williams
Jun 1, 1991·The American Review of Respiratory Disease·C SelbyW MacNee
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Oct 5, 1989·The New England Journal of Medicine·W MacNeeJ C Hogg
Jun 1, 1986·Experimental Cell Research·D A CarsonC J Carrera
Mar 1, 1982·The Journal of Investigative Dermatology·P P BradleyG Rothstein
Apr 29, 1983·Science·A Meister
Dec 1, 1994·Journal of Leukocyte Biology·T M WizemannD L Laskin
Oct 1, 1995·Archives of Biochemistry and Biophysics·M G SalgoW A Pryor
Nov 1, 1995·American Journal of Respiratory Cell and Molecular Biology·D M BrownW MacNee
Aug 7, 1995·FEBS Letters·V Darley-UsmarB Halliwell
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·J R BrittonS T Weiss
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·L M VillaS Moncada
Nov 1, 1994·European Journal of Pharmacology·D W LaightJ F Waterfall
Apr 1, 1994·The European Respiratory Journal·M K SridharS W Banham
Feb 1, 1994·Free Radical Biology & Medicine·N W KooyJ S Beckman
Nov 1, 1993·The American Review of Respiratory Disease·E M DrostW MacNee
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
Jun 1, 1996·British Journal of Pharmacology·D SalveminiM G Currie
Jul 1, 1996·Chemical Research in Toxicology·J S Beckman
Jul 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M OginoM Katori
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·I RahmanW MacNee
Jan 1, 1997·Free Radical Biology & Medicine·L FlohéL Packer
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·J E RepineI Lankhorst
Jan 1, 1997·Free Radical Biology & Medicine·H F GalleyN R Webster

❮ Previous
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Citations

Nov 8, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ana Paula Oliveira FerreiraCarlos Fernando Mello
May 24, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·E DoussetR Guieu
Mar 24, 2004·International Immunopharmacology·Victor M VictorMonica De la Fuente
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Klaus-D SchaserThomas Mittlmeier
Jan 17, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mehmet CağlikülekciSuha Aydin
Jan 21, 2006·Critical Care Medicine·Cristiane RitterFelipe Dal-Pizzol
Feb 18, 2009·The American Journal of Chinese Medicine·Ying-Chih LinWen-Huang Peng
Dec 8, 2009·American Journal of Respiratory and Critical Care Medicine·Changsuk MoonJihee Lee Kang
May 3, 2005·Biological & Pharmaceutical Bulletin·Risa KurozumiShuji Kojima
Mar 16, 2011·International Journal of General Medicine·Pietro Ghezzi
Apr 29, 2009·European Journal of Gastroenterology & Hepatology·Marina Galicia-MorenoPablo Muriel
Apr 22, 2010·Shock·Rosanna Di PaolaSalvatore Cuzzocrea
Sep 21, 2006·Free Radical Research·Ettore CrimiClaudio Napoli
Apr 28, 2009·Pulmonary Pharmacology & Therapeutics·Hisatoshi SugiuraStephen I Rennard
Apr 29, 2015·Journal of Biomedical Materials Research. Part a·Marcos M S PaulaRicardo A Pinho
Aug 11, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Naresh SinghBalaram Ghosh
Feb 27, 2007·Free Radical Biology & Medicine·Georgios K GlantzounisAlexander M Seifalian
Aug 16, 2005·Journal of Pineal Research·Tiziana GenoveseSalvatore Cuzzocrea
Apr 10, 2003·British Journal of Pharmacology·A Serrano-MollarO Bulbena
Oct 13, 2004·Pulmonary Pharmacology & Therapeutics·Oguz KokselUgur Oral
Aug 1, 2013·Environmental Toxicology·Manar Hamed ArafaHebatallah Husseini Atteia
Nov 27, 2009·Journal of Vascular Surgery·Michael A RosenbaumLinda M Graham
Nov 4, 2011·Journal of Vascular Surgery·Michael A RosenbaumLinda M Graham
Aug 1, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laura LucariniEmanuela Masini
Aug 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shafiq Ur RahmanMarcello Iriti
Jan 10, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Joshua HoltAmalia Cochran
Nov 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alip BorthakurJoanne K Tobacman

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