Protective effects of Na salicylate against digoxin- and BaCl2-induced arrhythmias in guinea-pigs

European Journal of Pharmacology
H Brasch


In pentobarbital-anaesthetized (60 mg/kg i.p.) guinea-pigs injections of Na salicylate (50 and 100 mg/kg i.v.) had a protective effect against arrhythmias induced by digoxin or BaCl2. A lower (25 mg/kg) and a higher (200 mg/kg) dose exerted no clearcut antiarrhythmic effect. Plasma concentrations of Na salicylate up to 1 mg/ml influenced neither the heart rate nor the ECG parameters. The antiarrhythmic effect of the drug may be explained by an inhibition of cardiac cyclooxygenase.

Related Concepts

Barium chloride, octaammoniate
Cardiac Arrhythmia
Diastolic Blood Pressure
Chloride Ion Level
Electrocardiographic Recorders
Cavia porcellus
Pulse Rate

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