Protective effects of nanoparticulate coenzyme Q10 and curcumin on inflammatory markers and lipid metabolism in streptozotocin-induced diabetic rats: a possible remedy to diabetic complications

Drug Delivery and Translational Research
Venkat Ratnam DevadasuM N V Ravi Kumar

Abstract

Diabetes and its complications have been linked to increased levels of free radicals and systemic pro-inflammatory cytokines and to an altered lipid profile. Coenzyme Q10 and curcumin are potent antioxidants and anti-inflammatory agents but are underutilized clinically because of their poor bioavailability when administered orally. We have recently developed poly(D,L-lactic-co-glycolic acid)-based nanoparticles in which we have encapsulated coenzyme Q10 and curcumin to increase the oral bioavailability and therapeutic efficacy of the antioxidant molecules. These formulations when tested in streptozotocin-induced diabetic rats demonstrated protective effects on inflammatory markers as well as lipid metabolism. Coenzyme Q10 nanoparticulates reduced only C-reactive protein levels, whereas curcumin nanoparticles reduced levels of C-reactive protein, interleukin-6 and tumor necrosis factor-α. Administration of both nanoparticulates resulted in significant reductions of plasma triglycerides and total cholesterol and an increase in high-density lipoprotein cholesterol. Together, these data indicate the promise of coenzyme Q10 and curcumin in diabetes when delivered through nanoparticulate formulations.

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Citations

Jun 1, 2013·Drug Delivery and Translational Research·Charitra N GramaM N V Ravi Kumar
Sep 4, 2015·The AAPS Journal·Murali M YallapuSubhash C Chauhan
May 4, 2013·International Journal of Pharmaceutics·Teresa Simón-YarzaMaria J Blanco-Prieto
Jan 10, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Venkat Ratnam DevadasuM N V Ravi Kumar
Apr 1, 2012·Drug Delivery and Translational Research·Deepak ChitkaraNeeraj Kumar
Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Jan 18, 2020·International Journal of Molecular Sciences·Danielle VitaliCharu Kaushic
Jul 8, 2020·Journal of Agricultural and Food Chemistry·Zeynep GoktasShu Wang

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