Abstract
Acetaminophen (N-acetyl-p-aminophenol, AAP) is an effective analgesic and antipyretic drug with minimal toxicity when used at therapeutic doses. However, AAP overdose is the most common cause of drug-induced acute liver failure and one of the main causes of morbidity and mortality. p-Coumaric acid (PCA) is the most abundant isomer of hydroxycinnamic acid in nature, and it can be widely found in fruits, vegetables, and plants products. PCA has strong antioxidant activity and exhibits protective effects in numerous disease models associated with reactive oxygen species (ROS) generation. In this study, we investigated the protective effects of PCA on AAP-induced hepatotoxicity and the underlying mechanisms using an in vivo model. We found that PCA ameliorates AAP-induced hepatotoxicity as well as the reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity. Furthermore, we observed that PCA suppressed hepatic apoptosis via ROS-mediated DNA damage responses and inflammation by modulating the mitogen-activated protein kinase (MAPK) signaling axis in an ROS-dependent manner. These findings indicate that the administration of PCA protects against AAP-induced hepatotoxicity, suggesting it could be a no...Continue Reading
Citations
Jan 23, 2020·Biomolecules·Fei-Xuan WangLing-Dong Kong
Dec 12, 2019·Inflammation·Xiaojian HuangHongbo You
Aug 29, 2019·Critical Reviews in Food Science and Nutrition·Anurag Khatkar, Krishna Kant Sharma
Mar 27, 2020·PloS One·Khanutsanan WoranamThanaset Senawong
Aug 7, 2019·Antioxidants·Yong Chool Boo
Jun 20, 2019·Oxidative Medicine and Cellular Longevity·Chien-Ta WuGuan-Jhong Huang
Mar 4, 2020·Nutrients·Maria Adriana NeagAnca Dana Buzoianu
Mar 13, 2021·Frontiers in Pharmacology·Ram BhartiNeeraj Khatri
Jul 10, 2021·Journal of Photochemistry and Photobiology. B, Biology·Sayan BiswasNanaocha Sharma
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Angelica KresnamurtiIwan Sahrial Hamid
Jan 10, 2020·Journal of Agricultural and Food Chemistry·Fan JiangYong-Jiang Xu
Feb 11, 2020·Food Research International·Fabíola Carina BilucaAna Carolina Oliveira Costa
Dec 19, 2019·Chemical Research in Toxicology·Adarsh SahuRamkishore Agrawal
Jan 14, 2021·Journal of Ginseng Research·Phil-Dong MoonHyun-Ja Jeong