Protective effects of phenolic fraction of blue honeysuckle fruits against UVA-induced damage to human keratinocytes

Archives of Dermatological Research
Alena SvobodováJitka Vostalová

Abstract

In this study, the UVA (photo)protective activity of the phenolic fraction of L. caerulea fruits (PFLC) was assessed in human keratinocytes HaCaT. The keratinocytes were pre- or post-treated with PFLC (1-250 mg/l) and exposed to UVA irradiation (10-30 J/cm(2)). The results showed that both pre- and post-treatment with PFLC significantly suppressed UVA-induced ROS production, which was also revealed as a decrease in intracellular lipid peroxidation and elevation of reduced glutathione. Protection was concentration-dependent with a maximum at 50 mg/l. These results suggest that PFLC attenuates UVA-induced oxidative stress by reduction of ROS generation and ROS-mediated damage. For this reason, PFLC has potentially skin-protective functions against the deleterious effects of sunlight.

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Citations

Aug 27, 2013·Journal of Photochemistry and Photobiology. B, Biology·Jitka VostálováAlena Rajnochová Svobodová
Oct 31, 2012·International Journal of Molecular Sciences·Haitian ZhaoLei Yao
Apr 24, 2012·Environmental Toxicology and Pharmacology·Celine HeuLaurence Nicod
Aug 19, 2014·Phytotherapy Research : PTR·Eunson HwangTae Hoo Yi
Mar 20, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Denisa SkarupovaAlena Rajnochova Svobodova
Jan 27, 2019·Food Science & Nutrition·You-Suk LeeHae-Jeung Lee
Jun 25, 2020·Antioxidants·Stefano PiazzaEnrico Sangiovanni
May 16, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M AmararathnaH P Vasantha Rupasinghe
Jul 4, 2009·Journal of Agricultural and Food Chemistry·Irena PalíkováJitka Ulrichová

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