Protective effects of Phyllanthus emblica against myocardial ischemia-reperfusion injury: the role of PI3-kinase/glycogen synthase kinase 3β/β-catenin pathway

Journal of Physiology and Biochemistry
Mahesh ThirunavukkarasuNilanjana Maulik

Abstract

Clinical studies of Phyllanthus emblica (P. emblica) have shown that it increases production of nitric oxide, glutathione, and high-density lipoprotein (HDL); decreases low-density lipoprotein (LDL), total cholesterol, triglycerides, and high-sensitivity C-reactive protein (hsCRP); and significantly inhibits platelet aggregation. The following study was designed to examine the effect of P. emblica treatment on myocardial ischemia-reperfusion (I/R) injury and identify the molecular targets and its underlying mechanism(s). Experimental animals were divided into four groups: control sham (CS), P. emblica sham (PS), control I/R (CIR), and P. emblica I/R (PIR). Rats in the P. emblica groups were gavaged with aqueous P. emblica solution (100 mg/kg body weight) for 30 days. After 30 days of gavaging, the I/R group underwent I/R surgery (45-min ischemia) followed by 4 or 30 days of reperfusion. Rats in the sham group underwent surgery without ligation. Left ventricular tissue samples, 4 and 30 days after I/R, were used for Western blot analysis and immunohistochemistry, respectively. Western blot analysis showed upregulation of phosphorylated Akt and GSK3-β and increased nuclear translocation of β-catenin in the PIR group versus CIR. P...Continue Reading

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Citations

Jul 19, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chenxue ZhangYang Yu
Nov 6, 2018·Journal of Cardiovascular and Thoracic Research·Fataneh Hashem-DabaghianSaeed Kianbakht
Jun 15, 2019·Histochemistry and Cell Biology·Dongmei SuYunjun Zhou
Feb 23, 2020·Journal of Alzheimer's Disease : JAD·Elham TeimouriRalph N Martins
Dec 17, 2020·Frontiers in Pharmacology·Roodabeh Bahramsoltani, Roja Rahimi
Mar 18, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Nan LiYudong Mu

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