Protective effects of pinostrobin on β-amyloid-induced neurotoxicity in PC12 cells.

Cellular and Molecular Neurobiology
Yan-Fang XianXiao-Ping Lai

Abstract

Beta-Amyloid peptide (Aβ), a major protein component of brain senile plaques in Alzheimer's disease (AD), has been considered as a critical cause in the pathogenesis of AD. Pinostrobin, a potent flavonoid inducer, is the major and most active ingredient of Folium cajani. The present study aimed to investigate whether pinostrobin could provide protective effect against Aβ(25-35)-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells. The PC12 cells were pretreated with different concentrations of pinostrobin for 2 h, followed by the challenge with 20 μM Aβ(25-35) for 24 h. The results showed that pretreatment with pinostrobin significantly elevated cell viability, decreased the lactate dehydrogenase activity, the levels of intracellular reactive oxygen species and calcium, and mitochondrial membrane potential in Aβ(25-35)-treated PC12 cells. In addition, pinostrobin significantly suppressed the formation of DNA fragmentation and increased the ratio of Bcl-2/Bax. These results indicate that pinostrobin was able to exert a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway...Continue Reading

References

Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·K HensleyD A Butterfield
Apr 1, 1997·Trends in Neurosciences·J Hardy
Sep 26, 1997·Nature·K PolyakB Vogelstein
Feb 25, 2000·European Journal of Pharmacology·A Berts, K P Minneman
Mar 25, 2000·Science·M J BerridgeM D Bootman
Aug 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H S KimY H Suh
Feb 7, 2002·Journal of Agricultural and Food Chemistry·Di WuDavid L DeWitt
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrey Y AbramovMichael R Duchen
Jun 20, 2006·Neurobiology of Aging·Cristina CecchiGianfranco Liguri
Jul 26, 2006·The Journal of Biological Chemistry·Brent L Kelly, Adriana Ferreira
Jan 15, 2008·Journal of Agricultural and Food Chemistry·Sam-Long Hwang, Gow-Chin Yen
Jun 25, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·So-Young ParkDonggeun Sul
Feb 14, 2009·Cellular and Molecular Neurobiology·Qing-Qiu MaoChun-Tao Che
Nov 2, 2011·Cellular and Molecular Neurobiology·Yan-Fang XianXiao-Ping Lai
Dec 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M MeckesR Mata

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Citations

Dec 15, 2015·Natural Product Research·Neeraj K PatelKamlesh K Bhutani
Oct 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chengbo GuZhiguo Liu
Feb 25, 2020·Critical Reviews in Food Science and Nutrition·Rana ShafabakhshZatollah Asemi
Mar 16, 2021·Journal of Ethnopharmacology·Lan WangJustin Che Yuen Wu
May 28, 2019·Current Medicinal Chemistry·Ze WangJing-Shan Shi
Jul 3, 2018·Journal of Agricultural and Food Chemistry·Chuwen LiSimon Ming-Yuen Lee

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