Protective effects of pogostone against LPS-induced acute lung injury in mice via regulation of Keap1-Nrf2/NF-κB signaling pathways

International Immunopharmacology
Chao-Yue SunZi-Ren Su

Abstract

Pogostone, a major component of Pogostemon cablin, has been demonstrated to possess antibacterial, anti-fungal, immunosuppressive and anti-inflammatory properties. To investigate the potential therapeutic effect of pogostone on lipopolysaccharide (LPS)-induced acute lung injury (ALI), mice were pretreated with pogostone prior to LPS exposure. After LPS challenge, the lungs were excised and the histological changes, wet to dry weight ratios, MPO activity reflecting neutrophil infiltration, and MDA activity reflecting oxidative stress were examined. The inflammatory cytokines in the BALF were determined by ELISA assay. Moreover, the expressions of p65 and phosphorylated p65 subunit of NF-κB, and Nrf2 in the nucleus in lung tissues were measured by Western blot analysis, and meanwhile the dependent genes of NF-κB and Nrf2 were assessed by RT-qPCR. The results showed that pretreatment with pogostone markedly improved survival rate, attenuated the histological alterations in the lung, reduced the MPO and MDA levels, decreased the wet/dry weight ratio of lungs, down-regulated the level of pro-inflammatory mediators including TNF-a, IL-1β and IL-6. Furthermore, pretreatment with pogostone enhanced the Nrf2 dependent genes including NQ...Continue Reading

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Citations

Mar 21, 2017·Biochemical and Biophysical Research Communications·Meihua JinDonghe Han
Nov 5, 2019·Frontiers in Pharmacology·Waikit LeongW L Wendy Hsiao
Sep 4, 2020·Phytotherapy Research : PTR·Sai Manohar ThotaVenketesh Sivaramakrishnan
Jan 6, 2021·Antioxidants·Melania Guerrero-HueJuan Antonio Moreno
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Apr 30, 2021·Pharmaceutical Biology·Guiying ZhangWenli Yin
Jun 26, 2021·Proceedings of the National Academy of Sciences of the United States of America·Takahiro KawasakiTakashi Satoh

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