Protective effects of polysaccharide fucoidin on myocardial ischemia-reperfusion injury in rats

Journal of Cardiovascular Pharmacology
M OmataT Ohno

Abstract

We tested whether polysaccharide fucoidin, which inhibits leukocyte rolling in the mesenteric venule, has protective effects in the rat myocardial 30-min ischemia and 6-h reperfusion injury model. Intravenous infusion of fucoidin (27 microg/kg/min from 10 min before to 6 h after reperfusion) significantly attenuated myocardial infarct size 6 h after reperfusion. In this ischemia and reperfusion heart model, expression of P-selectin (determined immunohistochemically) was observed on the venular endothelial cells in the heart 30 min after reperfusion and also was sustained after 6 h. Neutrophil infiltration as estimated by myeloperoxidase activity significantly increased 2 h after reperfusion and kept increasing with time until 6 h after reperfusion. Four-hour infusion of fucoidin after reperfusion significantly reduced neutrophil infiltration, whereas the 2-h infusion of fucoidin did not. These results indicate that neutrophil infiltration and myocardial injury are attributed to expression of P-selectin after reperfusion, and that one of the inhibitory mechanisms of fucoidin seems to be blockade of P-selectin-mediated neutrophil rolling on the vessel wall.

References

Jul 1, 1992·Hypertension·J I Goldhaber, J N Weiss
Feb 1, 1991·The Journal of Cell Biology·K D PatelT M McIntyre
Sep 1, 1990·The Journal of Cell Biology·Y ImaiS D Rosen
Aug 1, 1985·Circulation·A KerenR L Popp
Dec 1, 1993·The Journal of Clinical Investigation·O AbbassiC W Smith
Jan 3, 1994·European Journal of Pharmacology·D AltavillaA P Caputi
Feb 1, 1995·The Journal of Cell Biology·K L MooreR P McEver
May 5, 1995·The Journal of Biological Chemistry·S P ColganJ L Madara
Jun 1, 1995·The Journal of Clinical Investigation·P KubesD Payne
Mar 1, 1994·The Journal of Clinical Investigation·M BuerkeA M Lefer
Sep 1, 1994·Cardiovascular Research·M L Entman, C W Smith
Apr 1, 1993·Journal of the American College of Cardiology·A FarbR Virmani

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Citations

Jan 8, 2004·Microvascular Research·Andrew M RobertsDavid Lominadze
Feb 4, 1999·The Annals of Thoracic Surgery·L S RitterP F McDonagh
Jun 5, 2003·Burns : Journal of the International Society for Burn Injuries·Cengiz CetinYakup Karabağli
Sep 5, 2002·Clinical and Experimental Pharmacology & Physiology·Sven DittrichChristoph Bührer
Dec 8, 2011·Journal of Cardiovascular Pharmacology·Stéphane Manzo-SilbermanIbrahim Elmadbouh
Feb 9, 2010·Bioscience, Biotechnology, and Biochemistry·Yoshiharu TokitaTakeaki Nagamine
Sep 7, 2007·Digestive Diseases and Sciences·A R F BarretoG A C Brito
May 25, 2007·Archives of Physiology and Biochemistry·Alexander V OvechkinAndrew M Roberts
Jun 7, 2011·Burns : Journal of the International Society for Burn Injuries·Erol BenlierAhmet Cemal Aygit
Oct 21, 2015·Canadian Journal of Physiology and Pharmacology·Xiao-Jing Li, Qi-Fa Ye
Apr 30, 2002·Seminars in Immunology·Paul Kubes
Nov 13, 2012·Journal of Vascular Surgery·Jean-Marc AlsacJean-Baptiste Michel
Jan 18, 2005·Journal of the American College of Cardiology·José A BarrabésJordi Soler-Soler
Jan 26, 2013·Biochemical and Biophysical Research Communications·Tae Hee KimWon Seok Yang
Aug 3, 2016·Marine Drugs·Lucas CholletFrédéric Chaubet
Jan 5, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Komei TanakaYoshifusa Aizawa
Feb 14, 2007·Glycobiology·Albana CumashiUNKNOWN Consorzio Interuniversitario Nazionale per la Bio-Oncologia, Italy
Jan 16, 2018·Journal of Nutritional Science and Vitaminology·Yoshiharu TokitaTakeaki Nagamine
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M D'AmicoM Perretti
Mar 10, 2007·International Journal of Immunopathology and Pharmacology·J M LeitnerB Jilma
May 29, 2013·The Laryngoscope·Brian LawtonTimothy S Lian
Oct 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mei-Lin ChenYu-Hsin Lin
Aug 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·François RouzetDidier Letourneur
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·A S De VrieseM W Steinhausen
Aug 9, 2021·Carbohydrate Polymers·Yuan Yao, Evelyn K F Yim

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