Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Jung Ran ChoiHyun Young Kim

Abstract

In this study, we investigated the protective effects of protocatechuic acid (PA) against cognitive impairment in an amyloid-beta (Aβ)-induced Alzheimer's disease (AD) mouse model. PA was administered orally for 14 days at 100 and 200 mg/kg/day. To examine effects on cognition, we conducted behavior tests including the T-maze test, novel object recognition, and the Morris water maze test. In addition, we measured lipid peroxidation, nitric oxide (NO) production, and inflammation-related protein expression in mice tissues. The PA-administered group showed more use of novel routes, better novel object recognition, and learning and memory ability compared to the Aβ25-35-injected mice in the behavior tests. The results indicated that the administration of higher PA protected against cognitive impairment. In addition, the PA-administered groups showed significantly decreased lipid peroxidation and NO production in the brain, kidney, and liver tissues. Furthermore, the PA-administered groups showed attenuated Aβ25-35-induced neuroinflammation by downregulating inflammatory mediators, inducible nitric oxide synthase and cyclooxygenase-2 in the brain. The results of the present study suggest that PA may be a protective agent against AD.

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Apr 5, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Zhiyu XiLiuguan Bian
Sep 24, 2021·Journal of Agricultural and Food Chemistry·Hui XuMingfu Wang

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