Protective Effects of Protocatechuic Acid on Seizure-Induced Neuronal Death

International Journal of Molecular Sciences
Song Hee LeeSang Won Suh

Abstract

Protocatechuic acid (PCA) is a type of phenolic acid found in green tea and has been shown to have potent antioxidant and anti-inflammatory properties. However, the effect of PCA on pilocarpine seizure-induced neuronal death in the hippocampus has not been evaluated. In the present study, we investigated the potential therapeutic effects of PCA on seizure-induced brain injury. Epileptic seizure was induced by intraperitoneal (i.p.) injection of pilocarpine (25 mg/kg) in adult male rats, and PCA (30 mg/kg) was injected into the intraperitoneal space for three consecutive days after the seizure. Neuronal injury and oxidative stress were evaluated three days after a seizure. To confirm whether PCA increases neuronal survival and reduced oxidative injury in the hippocampus, we performed Fluoro-Jade-B (FJB) staining to detect neuronal death and 4-hydroxynonenal (4HNE) staining to detect oxidative stress after the seizure. In the present study, we found that, compared to the seizure vehicle-treated group, PCA administration reduced neuronal death and oxidative stress in the hippocampus. To verify whether a decrease of neuronal death by PCA treatment was due to reduced glutathione (GSH) concentration, we measured glutathione with N-et...Continue Reading

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Citations

Jul 8, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Olorunfemi R MolehinKehinde A Idowu
May 12, 2018·International Journal of Molecular Sciences·A Ra KhoSang Won Suh
Nov 13, 2020·Frontiers in Neuroscience·Dong Hyeon KangSang Won Suh
Dec 8, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Swapnil KaleRajesh R Ugale

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