Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells

Advanced Pharmaceutical Bulletin
Evgenii PlotnikovNikolay Bohan

Abstract

Purpose: Aim of present work was to study cytoprotective properties of lithium pyruvate, as a prospective pharmacological agent. Pyruvate has a lot of potential benefits due to positive influence on cell metabolism. Lithium is "gold-standard" mood-stabilizer. Combination of both may lead advantages. Methods: Lithium pyruvate was tested as cytoprotector on human blood mononuclears under induced oxidative stress. Cells were obtained from healthy donors and patients with alcoholism. The detection of cell viability, apoptosis and determination of oxidative stress level were conducted by flow cytometry. Results: Lithium pyruvate showed excellent cytoprotective properties in normal and oxidation conditions. This effect was independent from cell donor health status. It was shown on cells from healthy donors and alcoholics patients. Conclusion: Obtained results allow considering lithium pyruvate as potential normothymic agents (mood stabilizer) with excellent cytoprotective properties.

References

Jul 27, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Weihai YingRaymond A Swanson
Aug 28, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Todd D GouldHusseini K Manji
Jan 22, 2008·The International Journal of Neuropsychopharmacology·Felicity NgAshley I Bush
Feb 1, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena I KorotkovaOlesya A Voronova
Jun 14, 2014·Biomedical Journal·Barry Halliwell
Mar 2, 2017·Molecular and Cellular Biochemistry·Priscila Ramos-IbeasGiovanna Lazzari
Sep 9, 2017·Metallomics : Integrated Biometal Science·Magali Roux, Anthony Dosseto
Apr 18, 2018·The Journal of Surgical Research·Rui LiuFang-Qiang Zhou
Sep 3, 2018·Life Sciences·Verdiana RavarottoLorenzo A Calò
Dec 21, 2018·Journal of Pharmacy & Bioallied Sciences·Evgenii PlotnikovOlesya Voronova

❮ Previous
Next ❯

Citations

Apr 21, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E V Plotnikov, M M Litvak
Dec 20, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I S LosenkovN A Bokhan

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
Assay

Software Mentioned

SPSS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis