Protective effects of repetitive transcranial magnetic stimulation in a rat model of transient cerebral ischaemia: a microPET study.

European Journal of Nuclear Medicine and Molecular Imaging
Feng GaoHong Zhang

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to excite neurons in the brain. However, the underlying mechanism of its therapeutic effects in stroke remains unclear. The aim of this study was to investigate the neuroprotective effect of high-frequency rTMS in a rat model of transient cerebral ischaemia using positron emission tomography (PET). Sprague-Dawley rats (n=30) were anaesthetized with chloral hydrate and subjected to 90 min of intraluminal middle cerebral artery occlusion (MCAO) with subsequent reperfusion in three groups: control (n=10), rTMS (n=10), or sham-rTMS groups (n=10). In the rTMS group, rTMS was given 1 h after ischaemia and every 24 h for 7 days after MCAO. In all three groups, small-animal PET (microPET) imaging with (18)F-FDG was used to evaluate brain glucose metabolism. Apoptotic molecules were measured in the infarct margin using immunohistochemical staining. The neurological scores of the rats in the rTMS group were higher than in those of the control group over the whole 7-day observation period. The total, cortical and striatal infarct volumes were significantly less in the rTMS group than in the control group, as measured by 2,3,5-triphenyltetrazolium chloride staining...Continue Reading

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Citations

Oct 14, 2011·Neuromodulation : Journal of the International Neuromodulation Society·Chris KaoPeter Konrad
Jul 12, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Andrew M Vahabzadeh-HaghAlexander Rotenberg
Jun 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Yun-Young SunwooYoung-Min Han
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