Protective Effects of Simvastatin and Hesperidin against Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in Rats

Pharmacology
Yasmin Moustafa AhmedAli Ahmed Abo-Saif

Abstract

Rheumatoid arthritis (RA) is a disabling autoimmune disease for which most current treatments cause massive complications, thereby limiting treatment dose and duration. The anti-arthritic effects of the 3-hydroxy-3-metylglutary-CoA reductase inhibitor, simvastatin, and the natural flavonoid, hesperidin, were investigated against complete Freund's adjuvant-induced RA in rats. A normal control group, an arthritis control group, 2 reference treatment groups receiving dexamethasone (1.5 mg/kg/day) and methotrexate (1 mg/kg/day), and 2 treatment groups receiving simvastatin (0.5 mg/kg/day) and hesperidin (200 mg/kg/day) were included in the study. Serum rheumatoid factor, matrix metalloprotinease-3 (MMP-3) and cartilage oligomeric matrix protein (COMP) as specific rheumatoid biomarkers, serum immunoglobulin G (IgG) and antinuclear antibody (ANA) as immunological biomarkers, serum tumor necrosis factor-alpha and interleukin-10 as immunomodulatory cytokines, serum myeloperoxidase (MPO) and C-reactive protein as inflammatory biomarkers, and malondialdehyde (MDA) and glutathione (GSH) as oxidative stress biomarkers were assessed, supported by joint and spleen histopathological study. Simvastatin significantly improved all the measured b...Continue Reading

Citations

Jan 11, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yijia ZhangRichard A Reinhardt
Nov 23, 2016·Critical Reviews in Food Science and Nutrition·Samuel D HughesNagaraja Haleagrahara
Jan 24, 2018·Autoimmunity·Sahar Sobhy Abd-ElhalemNashwa Ahmed El-Shinnawy
Feb 18, 2017·Immunopharmacology and Immunotoxicology·Yasmin Moustafa AhmedAli Ahmed Abo-Saif
Sep 15, 2020·Archives of Insect Biochemistry and Physiology·Jaime J JayapalanOnn H Hashim
Dec 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Debolina ChakrabortySagarika Biswas

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