Protective effects of sinomenine against doxorubicin-induced nephrosis in rats

Journal of Asian Natural Products Research
Jie ZhangGuang-Ling Liu

Abstract

Sinomenine (SN, 1) is a pure compound extracted from the Sinomenium acutum plant. We investigated the protective effects and mechanism of action of SN in a rat model of doxorubicin (DOX)-induced nephrosis. Nephrosis was induced by a single dose of 5 mg/kg DOX, and DOX-treated rats received a daily i.p. injection of 10 or 30 mg/kg SN, or saline (n = 6). Urine and serum biochemical parameters, serum TNF-α and IL-1β levels, nephrin, podocin, α-actinin-4, and peroxisome proliferator-activated receptor-α (PPAR-α) protein expression, and renal ultrastructure were examined at day 28. Compound 1 significantly attenuated the effect of DOX on urine and serum biochemical parameters. Electron microscopy demonstrated that 1 suppressed DOX-induced increases in foot process width. Compared with those in control rats, nephrin, podocin, and PPAR-α protein expressions decreased in the glomeruli of DOX-treated rats, and this effect was significantly attenuated by 1. However, no appreciable alterations were observed in the expression level of α-actinin-4. DOX significantly increased serum TNF-α and IL-1β compared with those in control rats, and 1 significantly reduced the serum levels of TNF-α and IL-1β. SN ameliorates DOX-induced nephrotic syndro...Continue Reading

References

Oct 1, 1996·International Journal of Immunopharmacology·L LiuR W Kinne
Jan 22, 1998·The American Journal of Physiology·Y GuanM D Breyer
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Klaas KoopJan A Bruijn
Aug 29, 2003·Lancet·Allison A Eddy, Jordan M Symons
Sep 15, 2004·Pathology International·Na GuanJiyun Yang
Mar 26, 2005·Immunology Letters·Xiaobo HeXuetao Cao
Jun 9, 2005·American Journal of Physiology. Renal Physiology·Farid NakhoulZaid Abassi
Jun 15, 2005·International Immunopharmacology·Yongwen ChenYuzhang Wu
Dec 1, 2005·Kidney International·Kiran K NagothuDidier Portilla
Aug 8, 2006·Nephrology·Hiroshi KawachiFujio Shimizu
Sep 11, 2008·Biochemical and Biophysical Research Communications·Hua ZhouLiang Liu
Apr 9, 2010·Kidney International·Chunsun DaiYouhua Liu
Nov 27, 2010·International Immunopharmacology·Quanxing Wang, Xiao-Kang Li

❮ Previous
Next ❯

Citations

Jun 9, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Katsuhito NagaiHiroki Konishi
Apr 29, 2014·Journal of Ethnopharmacology·Camille DesgrouasEvelyne Ollivier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.