Protective effects of some antineoplastic agents on ischemia-reperfusion injury in epigastric island skin flaps

Microsurgery
Ibrahim AskarBilsel Bac

Abstract

Neutrophil depletion has a beneficial effect on ischemic myocardium and skeletal muscle upon reperfusion. Antineoplastic agents reduce blood neutrophils effectively, and lead to neutrophil depletion. The purpose of this study was to investigate the effects of four antineoplastic agents in low doses (cyclophosphamide, cisplatinum, mitomycin-C, and 5-fluorouracil) on ischemia-reperfusion injury, using an epigastric island skin-flap model in rats. Fifty male Sprague-Dawley rats, weighing 250-300 g, were randomly divided into five groups, each consisting of 10 rats: control, cyclophosphamide, cisplatinum, mitomycin-C, and 5-fluorouracil groups. Epigastric island skin flaps (measuring 3.5 x 4 cm) were raised and subjected to 10 h of in situ ischemia, followed by 7-day reperfusion and evaluation. Treatment with antineoplastic agents (cyclophosphamide, cisplatinum, mitomycin-C, and 5-fluorouracil) was used to introduce neutropenia. Complete blood counts, cutaneous bleeding time, and skin-flap survival were evaluated. Additionally, levels of malonyldialdehyde (MDA), nitric oxide (NO), glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were measured from extracted skin tissue. Numbers of leukocytes and pl...Continue Reading

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Citations

Feb 28, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Onder KaraaslanMehmet Berktas
Mar 21, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Marieke G W van den HeuvelRené R W J van der Hulst
Jun 10, 2008·Molecular Nutrition & Food Research·Hamid Namazi
Dec 18, 2020·Nature Communications·Connor H O' MearaChristopher R Parish

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