PMID: 9178284Apr 1, 1997Paper

Protective effects of succinic acid dimethyl ester infusion in experimental endotoxemia

Nutrition
W J MalaisseT M Zhang

Abstract

In rats injected with bacterial lipopolysaccharide (LPS; 5 gamma mg/g body weight [BWT]), the toxin provokes death within 24 h in 23% of the animals and, in surviving rats, causes a decrease in BWT, hyperlactacidemia, hyperlipacidemia, and hyperketonemia, as well as depletion of both liver and muscle glycogen content. In the liver, LPS severely lowers the ATP and total adenine nucleotide content, ATP/ADP ratio, and adenylate charge. In hepatocytes from LPS-injected rats, the oxidation of D-glucose is first increased 2 h after administration of the toxin, despite close-to-normal phosphorylation of the hexose. In hepatocytes prepared from rats killed 24 h after injection of LPS, the phosphorylation of D-glucose, its incorporation into glycogen, and its oxidation are all severely impaired. This sequence of changes, which coincides with a decreased ratio between pyruvate and lactate production from exogenous D-glucose, is comparable to that found with agents that uncouple oxidative phosphorylation. The injection of LPS also alters the metabolic response of hepatocytes to the dimethyl ester of succinic acid (SAD), in terms, for instance, of the sparing action of the ester upon both the production of 14CO2 by hepatocytes prelabeled w...Continue Reading

References

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Feb 1, 1987·Molecular and Cellular Endocrinology·M H GiroixW J Malaisse
Oct 15, 1984·European Journal of Biochemistry·A SenerW J Malaisse
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·R S Hotchkiss, I E Karl
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Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T M ZhangW J Malaisse

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Citations

Apr 7, 2010·Wiener medizinische Wochenschrift·Martina Wendel, Axel R Heller
Sep 7, 2006·Critical Care : the Official Journal of the Critical Care Forum·Alessandro Protti, Mervyn Singer
Nov 1, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ibrahim JallohKeri Lh Carpenter

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