Protective effects of sugar cane extract on endotoxic shock in mice

Phytotherapy Research : PTR
Maki MotobuYoshikazu Hirota

Abstract

Sugar cane extract (SCE) has been shown to have an immunostimulating effect in chickens. This study evaluated the effect of SCE on Salmonella Abortusequi lipopolysaccharide (LPS)-induced lethal shock in d-galactosamine (GalN)-sensitized mice. Mice were administered intraperitoneally SCE (500 mg/kg) or phosphate buffered saline before or after injection of LPS and GalN. All the mice injected with LPS and GalN (control group) died of histopathologically congestive and hemorrhagic hepatic insufficiency within 24 h, showing significantly increased activities of plasma aspartate aminotransferase (AST; 380 IU/mL) and alanine aminotransferase (ALT; 130 IU/mL). Pretreatment of mice with SCE at 3 h before challenge with LPS and GalN (SCE treated group) resulted in significantly improved survival rates (92.3%) and a decrease in liver injury. These surviving mice in the SCE treated group showed no changes in the mean levels of plasma AST (60 IU/mL) and ALT (18 IU/mL). However, the level of tumor necrosis factor-alpha in the SCE treated group was not significantly different when compared with that in the control group challenged with LPS and GalN. These results suggest that SCE has protective effects on LPS-induced mortality in this mouse ...Continue Reading

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Dec 25, 2002·The Journal of Veterinary Medical Science·Moshira El-AbasyYoshikazu Hirota
Feb 11, 2003·The Journal of Veterinary Medical Science·Moshira El-AbasyYoshikazu Hirota
Sep 3, 2003·The Journal of Veterinary Medical Science·Moshira El-AbasyYoshikazu Hirota
Feb 21, 2004·International Immunopharmacology·Said AmerYoshikazu Hirota
Jun 30, 2004·International Immunopharmacology·Moshira El-AbasyYoshikazu Hirota
Aug 23, 2005·Phytotherapy Research : PTR·Said AmerYoshikazu Hirota

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Citations

Oct 27, 2009·Biotechnology Letters·Sang Sik YunSeok Hyun Nam
May 20, 2014·The Kaohsiung Journal of Medical Sciences·Chih-Jen YangChao-Chuan Wang
Apr 9, 2016·Mediators of Inflammation·Jae Gwang ParkJae Youl Cho
Jul 10, 2016·Journal of Complementary & Integrative Medicine·Sarah MousaviMohsen Meidani
Jan 4, 2012·Phytotherapy Research : PTR·Ming-Hua ChenWei-Cheng Lee

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