Protective effects of the angiotensin type 1 receptor antagonist losartan in infection-induced and arthritis-associated alveolar bone loss

Journal of Periodontal Research
C M Queiroz-JuniorTarcília Aparecida da Silva

Abstract

The angiotensin type 1 (AT1) receptor has been implicated in the pathogenesis of inflammatory bone disorders. This study aimed to investigate the effect of an AT1 receptor antagonist in infection-induced and arthritis-associated alveolar bone loss in mice. Mice were subjected to Aggregatibacter actinomycetemcomitans oral infection or antigen-induced arthritis and treated daily with 10 mg/kg of the prototype AT1 antagonist, losartan. Treatment was conducted for 30 d in the infectious condition and for 17 d and 11 d in the preventive or therapeutic regimens in the arthritic model, respectively. The mice were then killed, and the maxillae, serum and knee joints were collected for histomorphometric and immunoenzymatic assays. In vitro osteoclast assays were performed using RAW 264.7 cells stimulated with A. actinomycetemcomitans lipopolysacharide (LPS). Arthritis and A. actinomycetemcomitans infection triggered significant alveolar bone loss in mice and increased the levels of myeloperoxidase and of TRAP(+) osteoclasts in periodontal tissues. Losartan abolished such a phenotype, as well as the arthritis joint inflammation. Both arthritis and A. actinomycetemcomitans conditions were associated with the release of tumor necrosis fact...Continue Reading

References

Mar 10, 1998·Journal of Cellular Physiology·S LamparterJ Pfeilschifter
Oct 16, 1999·Periodontology 2000·P M Fives-TaylorC Brissette
May 9, 2001·Current Opinion in Nephrology and Hypertension·M Ruiz-OrtegaJ Egido
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresa MateoMaria-Jesus Sanz
Dec 19, 2006·The Journal of Clinical Investigation·Yuhao GaoRoberto Pacifici
Feb 8, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hideo ShimizuRyuichi Morishita
Oct 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yutaro AsabaKyoji Ikeda
Nov 14, 2008·The Journal of Biological Chemistry·Yayoi IzuMasaki Noda
Feb 21, 2009·Journal of Periodontology·C F SantosM C O Salgado
Dec 8, 2010·Journal of Dental Research·D T GravesD L Cochran
Feb 26, 2011·Clinical & Developmental Immunology·Celso Martins Queiroz-JuniorTarcília Aparecida da Silva
Sep 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Celso Martins Queiroz-JuniorTarcília Aparecida da Silva
Oct 22, 2011·Microbes and Infection·Mila Fernandes Moreira MadeiraDaniele da Glória Souza
Mar 2, 2012·Nature Reviews. Drug Discovery·Kurt Redlich, Josef S Smolen
May 16, 2012·Journal of Clinical Periodontology·Celso Martins Queiroz-JuniorTarcília Aparecida da Silva
Dec 21, 2012·Annals of the Rheumatic Diseases·Steven R GoldringKevin P McHugh
Jan 11, 2013·Mediators of Inflammation·Jôice Dias CorrêaTarcília Aparecida da Silva
Jan 25, 2013·Arthritis·Yuki KawakamiKayo Masuko
Jun 19, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Aurigena Antunes AraújoRaimundo Fernandes de Araújo

❮ Previous
Next ❯

Citations

Aug 25, 2015·European Journal of Pharmacology·Mariam Gamal Fahmy WahbaAli Ahmed Abo-Saif
Aug 20, 2016·Journal of Periodontology·Lilian Gobbo GabrieleCarlos Ferreira Santos
Jul 25, 2019·Frontiers in Pharmacology·Sandra Helena Penha OliveiraCarlos Ferreira Santos
Oct 10, 2019·Journal of Applied Oral Science : Revista FOB·Gabriel Mulinari-SantosRoberta Okamoto
Jun 3, 2021·International Journal of Molecular Sciences·Maria Laura de Souza LimaAurigena Antunes de Araújo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here