Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats

Andrologia
Majid ShokoohiM Moghimian

Abstract

This study was designed to determine the effects of daily oral administration (250 mg/kg) of the hydroalcoholic extract of Fumaria parviflora (FP) for 14 days on the sperm parameters, oxidative stress parameters, serum testosterone levels, expression of Bax and Bcl-2 genes, and apoptosis index of germ cells after testicular torsion-detorsion (ischaemia-reperfusion, IR) injury model in rats. Twenty-eight adult male Wistar rats were divided randomly into four groups of seven each: sham operation, torsion-detorsion (TD), TD plus the hydroalcoholic extract FP (TDFP) and only FP without TD application (FP). Testicular torsion was created by rotating the left testis 720° in a counterclockwise direction; then, after 4 hr, detorsion was performed. The Johnson's score, mean seminiferous tubule diameter (MSTD) and height (thickness) of seminiferous tubule epithelium (HST) were significantly increased in TDFP and FP groups as compared to TD group. The gene expression of Bcl-2, level of serum testosterone hormone and antioxidant parameters-GPx and SOD-were significantly higher in TDFP and FP groups than TD group. The index of apoptosis, the gene expression of Bax and the level of MDA were significantly higher in TD group than TDFP and FP g...Continue Reading

References

Sep 1, 1989·The Journal of Urology·J H BaradaW J Cromie
Jul 31, 2003·BJU International·A J Visser, C F Heyns
Feb 24, 2005·Cancer Biology & Therapy·Zhaoyu Jin, Wafik S El-Deiry
Dec 20, 2008·Pakistan Journal of Biological Sciences : PJBS·Leila Roushangar, Jafar Soleimani Rad
Mar 31, 2009·Fertility and Sterility·Zehra KurcerEngin Sahna
Feb 22, 2011·TheScientificWorldJournal·Chao YangGuang-hui Wei
Apr 14, 2012·Journal of Pediatric Surgery·Jae-Won LeeJin Soo Han
Nov 6, 2012·Journal of Pediatric Urology·Zenon PogorelićDubravko Furlan
Nov 30, 2012·TheScientificWorldJournal·Seda OzbalZahide Cavdar
Jun 18, 2014·Nature Reviews. Urology·Ersagun KaraguzelOmer Kutlu
Dec 3, 2014·The Journal of Urology·Ozkan OzbekAzibe Yildiz
Mar 19, 2015·Journal of Pediatric Surgery·T Emre ŞenerGöksel Şener
Jul 23, 2016·Surgery Today·Jakov MeštrovićMarijana Popović
Jan 27, 2018·Cell Death & Disease·Caroline Maria Oliveira VolpeJosé Augusto Nogueira-Machado

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Citations

Nov 28, 2019·Andrologia·Asmaa Mohamed Abdel-Aziz, Sara Mohammed Naguib Abdel Hafez
Feb 21, 2019·Experimental Biology and Medicine·Hamed ShooreiHamidreza Pazoki-Toroudi
Feb 20, 2020·Pediatric Surgery International·Zhaobo XiaXiaokun Lin
Dec 13, 2019·BMC Complementary and Alternative Medicine·Kumpei TakahashiMasahiro Itoh
Mar 19, 2021·Drug Design, Development and Therapy·Hulya KasıkaraMustafa Kavutcu
Jan 1, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hamed ShooreiMajid Shokoohi
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·Jae Won LeeJin Soo Han
Jan 18, 2022·Veterinary Medicine and Science·Afrina MustariEmdadul Hauqe Chowdhury

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